Synthesis and biological properties of axially bis − (3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV)

dc.contributor.authorGüngördü Solgun, Derya
dc.contributor.authorÖzdemir, Sadin
dc.contributor.authorDündar, Abdurahman
dc.contributor.authorAğırtaş, Mehmet Salih
dc.date.accessioned2024-06-11T07:13:25Z
dc.date.available2024-06-11T07:13:25Z
dc.date.issued2024
dc.departmentMAÜ, Meslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractIn this study, bis − (3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV) was obtained from the reaction of 3,4,5-trimethoxybenzyl alcohol with SiPcCl2. This phthalocyanine was characterized using 1H NMR, FTIR, UV–vis and mass spectra. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, antidiabetic, deoxyribonucleic acid (DNA) cutting, biofilm inhibition, anti-microbial and antimicrobial photodynamic therapy (aPDT) activities of newly synthesized bis − (3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV) molecule were studied. The best activities were 41.58 % at 100 mg/L for antioxidant and 41.66 % for antidiabetic at 400 mg/L concentration. The molecule degraded the biofilm matrix formed by Pseudomonas aeruginosa and Staphylococcus aureus as 78.61 % and 89.26 %, at 50 mg/L concentration, respectively. It was observed that E. coli, which was used as a model microorganism, was inhibited at a level close to 100 % even at the lowest concentration of 50 mg/L. While double strand break was observed at 50 mg/L DNA cutting activity, it was determined that DNA was reduced to nucleotides at 100 and 200 mg/L. The Pc also displayed effective antimicrobial and aPDT abilities against pathogens. With the application of aPDT, the effectiveness of antimicrobial activity increased 2 to 4 times. These increase rates are very important. The main conclusion of the study was that the newly synthesized compound exhibited various effective biological activities such as effective antioxidant, antidiabetic, DNA cleavage, antimicrobial, aPDT, biofilm inhibition and microbial cell viability inhibition.
dc.identifier.citationGüngördü Solğun, D., Özdemir, S., Dündar, A., & Salih Ağırtaş, M. (2024). Synthesis and biological properties of axially bis − (3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (iv). Journal of Photochemistry and Photobiology A: Chemistry, 115794. https://doi.org/10.1016/j.jphotochem.2024.115794
dc.identifier.doi10.1016/j.jphotochem.2024.115794
dc.identifier.issn10106030
dc.identifier.scopus2-s2.0-85195019712
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jphotochem.2024.115794
dc.identifier.urihttps://hdl.handle.net/20.500.12514/5884
dc.identifier.volume456
dc.identifier.wosqualityN/A
dc.institutionauthorDündar, Abdurrahman
dc.institutionauthorid0000-0002-7930-1054
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Photochemistry and Photobiology A: Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntimicrobial
dc.subjectAntioxidant
dc.subjectBiofilm inhibition
dc.subjectFluorescence
dc.subjectSilicon phthalocyanine
dc.titleSynthesis and biological properties of axially bis − (3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV)
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
dundar.pdf
Boyut:
2.14 MB
Biçim:
Adobe Portable Document Format
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.15 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama: