The protective effects of sinapic acid on acute renal ischemia/reperfusion injury

dc.authorid0000-0003-1415-0563en_US
dc.contributor.authorUnsal, Velid
dc.contributor.authorkolukcu, Engin
dc.contributor.authorFirat, Fatih
dc.contributor.authorGevrek, Fikret
dc.date.accessioned2021-11-23T06:59:18Z
dc.date.available2021-11-23T06:59:18Z
dc.date.issued2021en_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractObjectives: The aim of this research was to investigate whether sinapic acid (SA) can alleviate oxidative damage, apoptosis, and inflammation in I/R induced renal injury. Methods: A total of 24 male rats were randomly separated into four groups as six rats in each group. Group 1 (Sham), Group 2 (I/R), Group 3 (I/R + SA, 10mg/kg), Group 4 (I/R + SA, 20 mg/kg). In order to evaluate kidney function serum BUN, Cr, and AST were measured in an autoanalyzer. SOD, GSH-Px, MDA, PC and NO oxidative stress parameters were measured with spectrophotometric methods and TNF-α, IL-1β, IL-6, KIM-1 and NGAL parameters were measured with the ELISA method. In addition, H&E method and immunohistochemical examinations were performed for histological evaluations of kidney tissue. Results: SA significantly decreases the increase in kidney damage, inflammation, oxidative stress, cell death and restore the decrease in antioxidant enzyme activities (p<0.05). Pre-treatment of the rats with SA reduces kidney dysfunction and morphological changes. Conclusions: The development of oxidative stress and lipid peroxidation seems to be the leading factors that accelerate inflammation and cell death during renal IRI. The antioxidant, anti-inflammatory, and anti-apoptotic features of SA displayed a renoprotective effect.en_US
dc.identifier.citationUnsal, V., Kolukcu, E., Firat, F., & Gevrek, F. (2021). The protective effects of sinapic acid on acute renal ischemia/reperfusion injury. In Turkish Journal of Biochemistry (Vol. 46, Issue 5, pp. 563–571). Walter de Gruyter GmbH. https://doi.org/10.1515/tjb-2021-0115en_US
dc.identifier.doi10.1515/tjb-2021-0115en_US
dc.identifier.endpage571en_US
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85118942138en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage563en_US
dc.identifier.trdizinid507044en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2021-0115
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85118942138&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=8023c28a454719410a7907a1ee97dbd8
dc.identifier.urihttps://hdl.handle.net/20.500.12514/2946
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000712261700011?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=D6glE3zTofonGJ9JVtx
dc.identifier.volume46en_US
dc.identifier.wosWOS:000712261700011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Journal of Biochemistryen_US
dc.relation.ispartofTurkish Journal of Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosis; Kidney; KIM-1; NGAL; Oxidative stress; Sinapic aciden_US
dc.titleThe protective effects of sinapic acid on acute renal ischemia/reperfusion injuryen_US
dc.title.alternativeSinapik asidin akut renal iskemi/reperfüzyon hasarı üzerine koruyucu etkilerien_US
dc.typeArticleen_US

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