Diagnostic Performance of Erythropoietin and Erythropoietin Receptors Levels in Children with Attention Deficit Hyperactivity Disorder
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Clinical Psychopharmacology and Neuroscience
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Attention deficit hyperactivity disorder (ADHD) is a heterogeneous, highly heritable, a common childhood neurobehavioural disorder resulting from complex gene-gene and gene-environment interactions. The erythropoietin (Epo)/erythropoietin receptors (EpoR) system turned out to have additional important functions in nonhematopoietic tissue. In this study, we aimed to investigate the levels of Epo and and EpoR, and also their diagnostic values in children with ADHD.
Methods: A total of 70 children were included in the study, 35 drug-naive patients with ADHD (age: 6−12 years; male/female: 20/15) and 35 healthy controls (age: 6−12 years; male/female: 22/13). Serum Epo and EpoR levels was determined using a commercial sandwich enzyme-linked immunosorbent assay kit.
Results: The results indicated that the levels of Epo decreased in patients with ADHD compared to control (p < 0.05). On the other hand, EpoR levels increased in these patients (p < 0.05). Furthermore, the ratio of Epo/EpoR was significantly lower in ADHD patients than controls (p < 0.05). Receiver operator characteristic curve analysis showed high diagnostic performance for Epo and EpoR, areas under curve were 0.980 and 1.000, respectively.
Conclusion: This is the first report to investigate the association between serum Epo and EpoR levels in ADHD patients. Our results indicated that Epo may play a role in the etiology of ADHD, and Epo therapy may be beneficial in these disorders if given in addition to the routine treatment of children with ADHD. Furthermore, our results reveal possible diagnostic value of Epo and EpoR.
Açıklama
Anahtar Kelimeler
Attention deficit hyperactivity disorder; Erythropoietin; Erythropoietin receptors
Kaynak
Clinical Psychopharmacology and Neuroscience
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
19
Sayı
3
Künye
Gungor M, Kurutas EB, Oner E, Unsal V, Altun H, Yalin AE, Yalin S, Bozkus O, Sahin N. Diagnostic Performance of Erythropoietin and Erythropoietin Receptors Levels in Children with Attention Deficit Hyperactivity Disorder. Clin Psychopharmacol Neurosci. 2021 Aug 31;19(3):530-536. doi: 10.9758/cpn.2021.19.3.530. PMID: 34294622.
Bağlantı
https://pubmed.ncbi.nlm.nih.gov/34294622/
https://doi.org/10.9758/cpn.2021.19.3.530
https://hdl.handle.net/20.500.12514/2718
https://www.scopus.com/record/display.uri?eid=2-s2.0-85111967562&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=c3f9ca4cff699401e40a57cce9a2311a
https://www.webofscience.com/wos/woscc/full-record/WOS:000677629700013?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=F66KvxZdJABQpoFFcFA
https://doi.org/10.9758/cpn.2021.19.3.530
https://hdl.handle.net/20.500.12514/2718
https://www.scopus.com/record/display.uri?eid=2-s2.0-85111967562&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=c3f9ca4cff699401e40a57cce9a2311a
https://www.webofscience.com/wos/woscc/full-record/WOS:000677629700013?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=F66KvxZdJABQpoFFcFA
