The effects of oxytocin on penile tissues in experimental priapism model in rats

dc.contributor.authorKolukçu, Engin
dc.contributor.authorKılıç, Şahin
dc.contributor.authorParlaktaş, Bekir Süha
dc.contributor.authorErdemir, Fikret
dc.contributor.authorÜnsal, Velid
dc.contributor.authorAtılgan, Doğan
dc.contributor.authorUluocak, Nihat
dc.date.accessioned14.07.201910:50:10
dc.date.accessioned2019-07-16T20:43:49Z
dc.date.available14.07.201910:50:10
dc.date.available2019-07-16T20:43:49Z
dc.date.issued2019
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractPurposeThis study aimed to demonstrate the effects of oxytocin on penile tissues in ischemia-reperfusion injury developed after priapism.MethodsForty Wistar Albino strain male rats were divided into four groups. The control group (n=10) was not intervened. In Group 2, a rat model of priapism was constructed and maintained for 1 h. In Group 3, reperfusion was ensured for 30min following priapism. Rats in Group 4 rats were given oxytocin 30min before the induction of reperfusion following priapism. All rats were penectomized, and adequate amounts of blood sample were drawn. Inflammation, vasocongestion, desquamation, and edema in penile tissue were scored between 0 and 3 points (0: normal, 1: mild, 2: moderate, 3: severe) to evaluate the severity of tissue damage. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the levels of malondialdehyde (MDA), and nitric oxide (NO) in blood samples were determined spectrophotometrically.ResultsIn histopathological examination, statistically significant positive changes were detected in vasocongestion, inflammation, desquamation, and edema scores in Group 4 than in Group 2 and Group 3 (p<0.001). Biochemical test results revealed that NO levels were significantly lower in Group 4 than in Group 3 (p<0.001). Serum GSH-Px activities in Group 4 significantly increased when compared with the other groups 2 and 3 (p=0.002, p=0.001, respectively). There was no statistical difference among the groups regarding SOD activities and MDA levels (p>0.05).ConclusionsOxytocin protected against priapism-induced ischemia-reperfusion injury developed in cavernosal tissue as observed based on histopathological and biochemical evidence. Although this is an experimental study, oxytocin can be thought as an alternative drug in the treatment of priapism.en_US
dc.identifier.doi10.1007/s11255-018-2046-zen_US
dc.identifier.endpage238en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue2en_US
dc.identifier.pmid30515737en_US
dc.identifier.scopus2-s2.0-85057719793en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-018-2046-z
dc.identifier.urihttps://hdl.handle.net/20.500.12514/1224
dc.identifier.volume51en_US
dc.identifier.wosWOS:000459537700007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜnsal, Velid
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofINTERNATIONAL UROLOGY AND NEPHROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectOxytocinen_US
dc.subjectPenile tissueen_US
dc.subjectPriapismen_US
dc.subjectRat modelen_US
dc.titleThe effects of oxytocin on penile tissues in experimental priapism model in ratsen_US
dc.typeArticleen_US

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