Relationship between premature ventricular contractions and cognitive functions
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Dosyalar
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Arrhythmias impair cerebral blood flow. Cognitive impairment (CI) caused by cerebral
hypoperfusion may be aggravated by premature ventricular contractions (PVCs). We aimed to study the
relationship between PVC counts on 24-hour ambulatory ECG monitoring (Holter) and cognitive impairment.
Methods: A total of 340 individuals, comprising 244 patients and 96 healthy controls were enrolled in the
research. All patients had routine blood testing conducted. ECG was conducted. Each subject had a 24-
hour Holter ECG performed. ECG parameters and Holter ECG were analyzed. The minimal mental state
examination (mini-MSE) test was administered, a validated global cognitive evaluation for detecting CI.
Results: The mean age of the study group was 44.84±12.89 years and the 44.56±13.58 years control group. There
was no appreciable difference among the groups for hematological and biochemistry blood tests (p>0.05). There
was a significant difference between the PVC frequency groups (minimal, occasional, and frequent) and the
control group in terms of mini-MSE components (except copying, p=0.145) (p<0.001). There was a significant
negative correlation between orientation, registration, attention and calculation, recall, and language from
mini-MSE components and both ECG parameters and HRV (except RMSSD and LF/HF) (p<0.001). There was
a substantial correlation between LF/HF and language (p<0.05). A significant negative correlation was between
copying with QTcd and TpTe/QTc (r = -,139, p<0.05 and r = -150, p<0.001). In univariate and multivariate
analysis, there was no statistically significant predictive factor of mini-MSE scores (p>0.05).
Conclusion: This study revealed that global cognitive functions decreased as the frequency of PVC increased,
especially in orientation and language scores of the mini-MSE.
Açıklama
Anahtar Kelimeler
Premature ventricular contraction, cognitive impairment, arrhythmia, Holter monitoring, heart rate variability
Kaynak
TURKISH JOURNAL OF HEALTH AND SPORT
WoS Q Değeri
Scopus Q Değeri
Cilt
4
Sayı
2
