Kölükçü, EnginAtılgan, DoğanKuyucu, Yunus EmreUnsal, VelidÖzbek, Latif Mustafa2021-10-272021-10-272021Kölükçü, E., Atılgan, D., Kuyucu, Y. E., Özbek, L. M., & Unsal, V. (2021). Relationship Between Lymph Node Metastasis and Lymph Node Density and Preoperative Neutrophil-Lymphocyte Ratio in Patients Undergoing Radical Cystectomy. In The Bulletin of Urooncology (Vol. 20, Issue 3, pp. 168–173). Galenos Yayinevi. https://doi.org/10.4274/uob.galenos.2021.1809https://www.webofscience.com/wos/woscc/full-record/WOS:000691807700009?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=F6osbIceNs2Sx3kDKrohttps://hdl.handle.net/20.500.12514/2913Objective: This study aimed to evaluate the relationship between the preoperative neutrophil-lymphocyte ratio (NLR) and lymph node metastasis and lymph node density after radical cystectomy in patients with invasive urinary bladder cancer. Materials and Methods: Data of 89 patients who underwent radical cystectomy were examined. Our study included only cases with stage 2 urothelial bladder cancer. They were classified according to the lymph node status based on the surgical specimen. Patients with negative results were classified as group 1 and those with positive results as group 2. Patients in group 2 were further evaluated in two subgroups according to their lymph node density. Accordingly, group 2A consisted of patients with lymph node density of <20%, and group 2B involved those with lymph node density of ≥20%. Groups were compared statistically according to NLR. Results: Of the patients, 71 (79.8%) were male. The patients’ mean ages and neutrophil and lymphocyte counts were 67.36±8.64 years, 6.89±3.02 K/µL, and 3.08±2.18 K/µL, respectively. NLRs of groups 1 and 2 were 2.80±2.25 and 4.59±2.97, respectively. The relationship between group 1 and 2 tumors was significant (p=0.008). NLR values were 3.82±2.49 and 5.20±3.25 in groups 2A and 2B, respectively. However, no significant relationship was found between these values (p=0.235). Conclusion: Although no positive correlation was found between NLR and lymph node density, we think that this inflammation marker is an invaluable parameter to predict lymph node metastasisen10.4274/uob.galenos.2021.1809info:eu-repo/semantics/openAccessLymphocyte, neutrophil, bladder cancer, cystectomyArticleN/AWOS:000691807700009506313