Alhilal, SuzanAlhilal, MohammadGomha, Sobhi M.Ouf, Salama A.2022-10-252022-10-252022Alhilal, S., Alhilal, M., Gomha, S. M., & Ouf, S. A. (2022). Synthesis and biological evaluation of new aza-acyclic nucleosides and their hydrogen complexes from indole. Research on Chemical Intermediates, 48(8), 3567-3587.https://www.webofscience.com/wos/woscc/full-record/WOS:000819274600001?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=EUW1ED0AA4wPbESzeKvWLTjqIZtmjhttps://www.scopus.com/record/display.uri?eid=2-s2.0-85133290985&origin=resultslist&sort=plf-f&src=s&st1=10.1007%2fs11164-022-04760-3&sid=fdd1d64269c1f2a06aef897666292db7&sot=b&sdt=b&sl=31&s=DOI%2810.1007%2fs11164-022-04760-3%29&relpos=0&citeCnt=0&searchTerm=https://hdl.handle.net/20.500.12514/3149Three novel aza-acyclic nucleosides and two hydrogen complexes were isolated by flash chromatography after being produced in a reaction between indole and dibenzosulfonyl diethylamine (which had previously been prepared) in the presence of sodium and absolute ethanol as a basic catalyst. Structures of new compounds and complexes were determined by 1D-NMR: 1H NMR, 13C NMR, DEPT-135, 2D-NMR: COSY, HMQC, HSQC, HMBC, IR, and MS spectroscopy. The synthesized compounds were evaluated against a wide range of microorganisms, including Gram-positive and Gram-negative bacteria as well as fungal strains. These compounds showed good biological activity.en10.1007/s11164-022-04760-3info:eu-repo/semantics/closedAccessNitrogen-based · Indole · Aza-acyclic nucleosides · Acyclovir analoguesArticle48835673587Q2N/AWOS:0008192746000012-s2.0-85133290985