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dc.contributor.authorAktepe, Necmettin
dc.contributor.authorKoçyiğit, Abdurrahim
dc.contributor.authorYükselten, Yunus
dc.contributor.authorTaşkın, Abdullah
dc.contributor.authorKeskin, Cumali
dc.contributor.authorÇelik, Hakim
dc.date.accessioned14.07.201910:50:10
dc.date.accessioned2019-07-16T20:44:04Z
dc.date.available14.07.201910:50:10
dc.date.available2019-07-16T20:44:04Z
dc.date.issued2015
dc.identifier.citationAktepe, N., Kocyigit, A., Yukselten, Y., Taskin, A., Keskin, C., & Celik, H. (2015). Increased DNA Damage and Oxidative Stress Among Silver Jewelry Workers. Biological Trace Element Research, 164(2), 185–191. https://doi.org/10.1007/s12011-014-0224-0
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.urihttps://doi.org/10.1007/s12011-014-0224-0
dc.identifier.urihttps://hdl.handle.net/20.500.12514/1375
dc.descriptionWOS: 000351439700004en_US
dc.descriptionPubMed ID: 25575665en_US
dc.description.abstractSilver has long been valued as a precious metal, and it is used to make ornaments, jewelry, high-value tableware, utensils, and currency coins. Human exposures to silver and silver compounds can occur oral, dermal, or by inhalation. In this study, we investigated genotoxic and oxidative effects of silver exposure among silver jewelry workers. DNA damage in peripheral mononuclear leukocytes was measured by using the comet assay. Serum total antioxidative status (TAS), total oxidative status (TOS), total thiol contents, and ceruloplasmin levels were measured by using colorimetric methods among silver jewelry workers. Moreover, oxidative stress index (OSI) was calculated. Results were compared with non-exposed healthy subjects. The mean values of mononuclear leukocyte DNA damage were significantly higher than control subjects (p < 0.001). Serum TOS, OSI, and ceruloplasmin levels were also found to be higher in silver particles exposed group than those of non-exposed group (p < 0.001, p < 0.001, p < 0.01, respectively). However, serum TAS levels and total thiol contents of silver exposed group were found significantly lower (p < 0.05, p < 0.001, respectively). Exposure to silver particles among silver jewelry workers caused oxidative stress and accumulation of severe DNA damage.en_US
dc.language.isoengen_US
dc.publisherHUMANA PRESS INCen_US
dc.identifier.doi10.1007/s12011-014-0224-0en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDNA damageen_US
dc.subjectSilveren_US
dc.subjectOxidative stressen_US
dc.subjectComet assayen_US
dc.subjectCeruloplasminen_US
dc.subjectThiolen_US
dc.titleIncreased DNA Damage and Oxidative Stress Among Silver Jewelry Workersen_US
dc.typearticleen_US
dc.relation.ispartofBIOLOGICAL TRACE ELEMENT RESEARCHen_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümüen_US
dc.identifier.volume164en_US
dc.identifier.issue2en_US
dc.identifier.startpage185en_US
dc.identifier.endpage191en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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