Mardin Artuklu Üniversitesi Kurumsal Akademik Arşivi
DSpace@Artuklu, Mardin Artuklu Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Renoprotective effect of diacerein in rats with partial unilateral ureteral obstruction model
(WALTER DE GRUYTER, 2024) Kölükçü, Engin; Unsal, Velid; Fırat, Fatih; Gevrek, Fikret; Katar, Muzaffer
Objectives: We aimed to analyze the effects of diacerein in a rat model of partial unilateral ureteral obstruction (PUUO). Methods: We randomly divided 24 female rats into three groups. Control group, PUUO group and PUUO + diacerein group. The PUUO group was subjected to the PUUO model for seven days. The PUUO + diacerein group received oral diacerein (80 mg/kg) for seven days. Spectrophotometric methods were employed to measure oxidative stress parameters, including malondialdehyde (MDA), protein carbonyl (PC) and antioxidant enzyme levels, including glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD), while indicators of renal function, such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinous-associated lipocalin (NGAL), along with inflammatory parameters interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), were assessed using the ELISA method. Inflammatory parameters were measured in blood samples, and other parameters were analyzed in kidney tissue. Hematoxylin-eosin method examinations were used for histological analyses. Results: IL-1beta, TNF-alpha, and IL-6 levels were found to be significantly decreased in the PUUO + diacerein group compared to the PUUO group (p=0.006, p=0.002 and p=0.001, respectively). In the PUUO + diacerein group, GSH-Px and SOD activities increased compared with the PUUO group (p=0.031 and p=0.037, respectively). We also observed a significant improvement in renal function parameters, such as KIM-1 and NGAL levels in the PUUO + diacerein group compared to PUUO (p=0.002 and p=0.012, respectively). The PC and MDA levels were highest in the PUUO group (p<0.001). Similarly, the histopathologic tissue damage was the most prominent PUUO group (p<0.001). Conclusions: Our study found that diacerein is a highly effective pharmacologic agent in alleviating oxidative damage in PUUO model rats.
Politik Kararlar Almada Dindarlığın Etkisi Nedir? Yetişkinler Üzerine Nicel Bir Araştırma
(Anadolu İlahiyat Akademisi, 2024) Dökücü, Doğan Bekir; Ayten, Ali
Seçimler sırasında bireyin oy vereceği adaya veya partiye karar vermesine karşılık gelen politik karar verme, bilişsel bir süreç sonucunda ortaya çıkmaktadır. Seçmenler politik karar verme sürecinde farklı karar verme tarzları kullanmakta ve bireylerin kullandıkları karar verme tarzları bir dizi faktöre bağlı olarak değişmektedir. Bu faktörlerden birinin bireylere hayat tarzı, düşünme sistemi ve dünyaya bakış açısı sunan din ve dindarlık olduğu düşünülmektedir. Bu çerçevede makalede kişilerin politik karar verme tarzları ile dindarlık düzeyleri arasındaki ilişki incelenmiştir. Bununla birlikte oy vermeyi dinî bir görev olarak görmenin dindarlık ile politik karar alma tarzları ilişkisindeki düzenleyici rolü de incelenmiştir. Araştırmanın çalışma grubunu, İstanbul’un farklı ilçelerinde ikamet etmekte olan yaşları 25 - 65 yaş arasında değişen 310 katılımcı oluşturmaktadır. Kişisel Bilgi Formu, Politik Karar Verme Ölçeği ve Dindarlık Ölçeği veri toplamak için kullanılmıştır. Araştırma verileri Kasım-2021 tarihinde yüzyüze şekilde toplanmıştır. Bulgular politik karar verme tarzları ile dindarlık eğilimleri arasında güçlü ilişkilere işaret etmiştir. Nitekim bireylerin dindarlık eğilimleri arttıkça daha hızlı ve daha kolay politik karar vermeyi sağlayan tarzlara yönelik eğilimlerinin arttığı tespit edilmiştir. Dindarlığı daha yüksek olan bireyler hızlı ve sade, bilişsel kısayol temelli, partizan ve içgörüsel karar verme tarzlarına daha fazla eğilim göstermektedir. Dindarlık ile analitik karar verme tarzı arasındaki ilişkiye yönelik yapılan analizlerde ise bu iki değişken arasında ilişki olduğu ve bilgi-ibadet boyutuna yönelik eğilimin analitik karar verme tarzına yönelik eğilimi artırdığı görülmüştür. Yine bulgulara göre oy vermeyi dinî bir görev olarak görme dindarlık ve analitik karar verme arasında düzenleyici etkiye sahiptir. Daha açık bir ifadeyle oy vermeyi dinî bir görev olarak görmenin dindarlığın analitik karar vermeye olan etkisini artırdığı tespit edilmiştir.
Determination of chemical composition and antioxidant, cytotoxic, antimicrobial, and enzyme inhibition activities of Rumex acetosella L. plant extract
(Springer, 2024) İrtegün Kandemir, Sevgi; Aktepe, Necmettin; Baran, Ayşe; Baran, Mehmet Fırat; Atalar, Mehmet Nuri; Keskin, Cumali; Karadağ, Musa; Eftekhari, Aziz; Alma, Mehmet Hakkı; Zor, Murat; Aliyeva, Immi; Khalilov, Rovshan
Purpose: The phenolic composition, antioxidant, antimicrobial activity, enzyme inhibition activity, and cytotoxic activity potentials of the plant Rumex acetosella L. (R. acetosella) were examined in this study. Materials and Methods: The chemical composition of R. acetosella methanol extract was identified by the LC–MS/MS method. The antioxidant activity was tested using β-carotene/linoleic acid, DPPH free radical scavenging, ABTS cation radical scavenging, CUPRAC reducing power, and metal chelating activity methods. The cytotoxic activity was determined by the MTT assay using human ovarian adenocarcinoma (Skov-3), glioblastoma (U87), human dermal fibroblasts (HDF), and human colorectal adenocarcinoma (CaCo-2) cell lines. The antimicrobial activity of methanolic extracts was tested on gram-negative (Escherichia coli and Pseudomonas aeuriginosa) and gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) using the in vitro minimum inhibition concentration method (MIC). Enzyme inhibition activity of R. acetosella methanol extract was measured spectrophotometrically against acetylcholinesterase (AChE) and glutathione S-transferase (GST) enzymes. Results: The findings showed that the major components of the methanol extract content were luteolin-7-O-glucoside (1.599 m/L), polydatin (91,024 m/L), and shikimic acid (0.773 m/L). It was determined that the extract and standard antioxidant (a-tocopherol) results in DPPH•, and ABTS• + tests performed to determine the antioxidant activity were close to each other, and this value was more effective than the standard antioxidant (α-tocopherol) in the CUPRAC test. These results suggested that the plant’s antioxidant potential was higher when compared with reference antioxidant compounds. It was determined that the methanol extract of R. acetosella had a weaker effect on the growth of the tested microorganisms than the antibiotics used as standard. The activity of the GST and AChE enzymes was found to be severely inhibited by the methanol extract of R. acetosella. Conclusion: Based on these findings, R. acetosella L. is a medicinal and commercially beneficial plant that warrants further investigation.
The quality problems at low irradiance in the grid-connected photovoltaic systems
(Springer, 2024) Adak, Süleyman; Cangi, Hasan
Solar photovoltaic (PV) energy is one of the most prominent topics that have attracted the attention of researchers in recent years. The use of solar energy is increasing rapidly in the world. Although using PV energy has various advantages, it has some disadvantages. Among these disadvantages, power factor (PF) and total harmonic distortion (THD) issues are discussed in this article. When solar PV systems are integrated into the grid, various power quality problems arise. In addition, due to low power quality and high harmonics, power system components overheat and start operating in undesirable regions; causes great damage. The magnitude of PF and THD is dependent on solar irradiation values. In order to determine how the power quality in the grid-connected solar system is affected by changes in solar irradiation (G), results for various irradiation situations are presented and analyzed. In addition, at low irradiance values, the amplitude of harmonic components and reactive power increases, whereas the power factor of the PV system decreases. Low power factor and high amplitude of harmonics cause the efficiency of the solar system to decrease. In this study, PF and THDI values were measured on a particular cloudy day for analysis. An analysis of the solar PV system was conducted using Matlab/simulation program to model the grid-connected PV system. Thus, the analytical expression of the PF and THDI, which are dependent on irradiation, was found with a new method by using the Statistical Package for the Social Sciences (SPSS) program and the curve fitting method. Obtaining the analytical expressions for both solar irradiation (G) and power factor (PF) used the SPSS program and also solar irradiation (G) and total harmonic distortion (THDI) used the MATLAB curve fitting method which contributed to the science comparing to the existing literature. It can be prevented the low power quality by using such these expressions at low solar irradiation cases.
Prognostic significance of the chemerin level in coronavirus disease 2019 patients
(Wolters Kluwer Health, Inc., 2024) Gökdemir, Gül Şahika; Gökdemir, Mehmet Tahir; Araç, Songül; Yokuş, Beran
Increased serum chemerin levels have been reported in several inflammatory diseases. Few studies have investigated the relationship between chemerin and clinical features of COVID-19. Thus, chemerin may modulate the development and progression of COVID-19. We compared the serum chemerin concentration between patients with and without SARS-CoV-2 infection and its association with the severity and prognosis of COVID-19 pneumonia. This is a prospective, single-center, cross-sectional study. We enrolled COVID-19 patients who presented to our tertiary hospital and healthy controls. The COVID-19 patients were conducted and the dates of symptom onset were recorded. After admission to the hospital and stabilization, blood samples were obtained for routine hemogram, biochemistry, and chemerin. The chemerin level was 37.93 ± 17.3 ng/mL in patients followed in the ICU, 29.41 ± 12.79 ng/mL in inpatients, 30.48 ± 10.86 ng/mL in outpatients, and 25.12 ± 9.82 ng/mL in healthy controls. The difference between patients treated in the ICU and healthy controls was significant (P < .001). The high-sensitivity C-reactive protein (hs-CRP), ferritin, procalcitonin (PCT), and D-dimer levels were significantly higher in the intensive care unit (ICU) group (P < .001). Moreover, the chemerin level of patients who died was significantly higher than that of those who survived (P < .001). The chemerin level was increased in COVID-19 patients and also increased with increasing disease severity. The chemerin level was higher in the COVID-19 patients than healthy controls and was significantly higher in patients who died compared to those who did not.
