Mardin Artuklu Üniversitesi Kurumsal Akademik Arşivi
DSpace@Artuklu, Mardin Artuklu Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Pelvic floor muscle strength and dysfunctions in women with pes planus: A case-control study
(Elsevier, 2024) Toprak Şelenay, Ceyda; Yardımcı, Fatma Betül; Altay, Hafize
Background/aim: Distal extremity misalignment may give rise to pelvic floor dysfunctions (PFDs). This study aimed to compare pelvic floor muscle strength (PFMS) and dysfunctions in women with and without pes planus. Materials and methods: Women with (pes planus group, n = 30) and without pes planus (control group, n = 30) were included. The presence of PFDs questioned. Pes planus with the Feiss Line Test, PFMS with the Modified Oxford Scale, and the severity of PFDs with the Pelvic Floor Distress Inventory-20 (PFDI-20), including three subscales (Pelvic Organ Distress Inventory-6 (POPDI-6) for pelvic organ prolapse, Colorectal-Anal Distress Inventory-8 (CRADI-8) for colorecto-anal symptoms, and Urinary Distress Inventory-6 (UDI-6) for urinary symptoms, were assessed. Results: It was seen that no difference was found between groups in terms of PFMS (p > 0.05). However, urinary incontinence and anal incontinence were higher in women with pes planus than in women without pes planus (p < 0.05). Only the PFDI-20, CRADI-8, and UDI-6 scores were higher in women with pes planus compared to controls (p < 0.05). There was no difference was found between groups in terms of POPDI-6 scores (p > 0.05). Conclusion: The PFMS did not change according to the presence of pes planus. However, the prevalence of PFDs and their severity were higher in women with pes planus in comparison to controls. Posture assessments of individuals with PFDs, especially examination of foot posture, and pelvic floor assessments of individuals with posture disorders should be considered.
Are Lesson Plans Created by ChatGPT More Effective? An Experimental Study
(INT SOC TECHNOLOGY EDUCATION, 2024) Karaman, Muhammet Remzi; Göksu, İdris
In this research, we aimed to determine whether students' math achievements improved using ChatGPT, one of the chatbot tools, to prepare lesson plans in primary school math courses. The research was conducted with a pretest-posttest control group experimental design. The study comprises 39 third-grade students (experimental group = 24, control group = 15). The implementation process lasted five weeks and 25 lesson hours. In the experimental group, lessons were taught according to plans prepared using ChatGPT, while in the control group, existing lesson plans were used. Students' academic achievement was measured with a multiple-choice achievement test of 25 questions with two separate questions for each learning objective. According to the results, students' academic achievement increased significantly (d = 1.268) in math lessons taught according to lesson plans prepared using the ChatGPT. Although there was a difference between the posttest scores of the experimental group and the control group in favor of the experimental group, it was determined that this difference was not significant. These results show that teaching primary school math according to lesson plans prepared using ChatGPT is effective in academic achievement. Teachers should consider ChatGPT and their plans, combining them and benefiting from both in the implementation process.
Renoprotective effect of diacerein in rats with partial unilateral ureteral obstruction model
(WALTER DE GRUYTER, 2024) Kölükçü, Engin; Unsal, Velid; Fırat, Fatih; Gevrek, Fikret; Katar, Muzaffer
Objectives: We aimed to analyze the effects of diacerein in a rat model of partial unilateral ureteral obstruction (PUUO). Methods: We randomly divided 24 female rats into three groups. Control group, PUUO group and PUUO + diacerein group. The PUUO group was subjected to the PUUO model for seven days. The PUUO + diacerein group received oral diacerein (80 mg/kg) for seven days. Spectrophotometric methods were employed to measure oxidative stress parameters, including malondialdehyde (MDA), protein carbonyl (PC) and antioxidant enzyme levels, including glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD), while indicators of renal function, such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinous-associated lipocalin (NGAL), along with inflammatory parameters interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), were assessed using the ELISA method. Inflammatory parameters were measured in blood samples, and other parameters were analyzed in kidney tissue. Hematoxylin-eosin method examinations were used for histological analyses. Results: IL-1beta, TNF-alpha, and IL-6 levels were found to be significantly decreased in the PUUO + diacerein group compared to the PUUO group (p=0.006, p=0.002 and p=0.001, respectively). In the PUUO + diacerein group, GSH-Px and SOD activities increased compared with the PUUO group (p=0.031 and p=0.037, respectively). We also observed a significant improvement in renal function parameters, such as KIM-1 and NGAL levels in the PUUO + diacerein group compared to PUUO (p=0.002 and p=0.012, respectively). The PC and MDA levels were highest in the PUUO group (p<0.001). Similarly, the histopathologic tissue damage was the most prominent PUUO group (p<0.001). Conclusions: Our study found that diacerein is a highly effective pharmacologic agent in alleviating oxidative damage in PUUO model rats.
Politik Kararlar Almada Dindarlığın Etkisi Nedir? Yetişkinler Üzerine Nicel Bir Araştırma
(Anadolu İlahiyat Akademisi, 2024) Dökücü, Doğan Bekir; Ayten, Ali
Seçimler sırasında bireyin oy vereceği adaya veya partiye karar vermesine karşılık gelen politik karar verme, bilişsel bir süreç sonucunda ortaya çıkmaktadır. Seçmenler politik karar verme sürecinde farklı karar verme tarzları kullanmakta ve bireylerin kullandıkları karar verme tarzları bir dizi faktöre bağlı olarak değişmektedir. Bu faktörlerden birinin bireylere hayat tarzı, düşünme sistemi ve dünyaya bakış açısı sunan din ve dindarlık olduğu düşünülmektedir. Bu çerçevede makalede kişilerin politik karar verme tarzları ile dindarlık düzeyleri arasındaki ilişki incelenmiştir. Bununla birlikte oy vermeyi dinî bir görev olarak görmenin dindarlık ile politik karar alma tarzları ilişkisindeki düzenleyici rolü de incelenmiştir. Araştırmanın çalışma grubunu, İstanbul’un farklı ilçelerinde ikamet etmekte olan yaşları 25 - 65 yaş arasında değişen 310 katılımcı oluşturmaktadır. Kişisel Bilgi Formu, Politik Karar Verme Ölçeği ve Dindarlık Ölçeği veri toplamak için kullanılmıştır. Araştırma verileri Kasım-2021 tarihinde yüzyüze şekilde toplanmıştır. Bulgular politik karar verme tarzları ile dindarlık eğilimleri arasında güçlü ilişkilere işaret etmiştir. Nitekim bireylerin dindarlık eğilimleri arttıkça daha hızlı ve daha kolay politik karar vermeyi sağlayan tarzlara yönelik eğilimlerinin arttığı tespit edilmiştir. Dindarlığı daha yüksek olan bireyler hızlı ve sade, bilişsel kısayol temelli, partizan ve içgörüsel karar verme tarzlarına daha fazla eğilim göstermektedir. Dindarlık ile analitik karar verme tarzı arasındaki ilişkiye yönelik yapılan analizlerde ise bu iki değişken arasında ilişki olduğu ve bilgi-ibadet boyutuna yönelik eğilimin analitik karar verme tarzına yönelik eğilimi artırdığı görülmüştür. Yine bulgulara göre oy vermeyi dinî bir görev olarak görme dindarlık ve analitik karar verme arasında düzenleyici etkiye sahiptir. Daha açık bir ifadeyle oy vermeyi dinî bir görev olarak görmenin dindarlığın analitik karar vermeye olan etkisini artırdığı tespit edilmiştir.
Determination of chemical composition and antioxidant, cytotoxic, antimicrobial, and enzyme inhibition activities of Rumex acetosella L. plant extract
(Springer, 2024) İrtegün Kandemir, Sevgi; Aktepe, Necmettin; Baran, Ayşe; Baran, Mehmet Fırat; Atalar, Mehmet Nuri; Keskin, Cumali; Karadağ, Musa; Eftekhari, Aziz; Alma, Mehmet Hakkı; Zor, Murat; Aliyeva, Immi; Khalilov, Rovshan
Purpose: The phenolic composition, antioxidant, antimicrobial activity, enzyme inhibition activity, and cytotoxic activity potentials of the plant Rumex acetosella L. (R. acetosella) were examined in this study. Materials and Methods: The chemical composition of R. acetosella methanol extract was identified by the LC–MS/MS method. The antioxidant activity was tested using β-carotene/linoleic acid, DPPH free radical scavenging, ABTS cation radical scavenging, CUPRAC reducing power, and metal chelating activity methods. The cytotoxic activity was determined by the MTT assay using human ovarian adenocarcinoma (Skov-3), glioblastoma (U87), human dermal fibroblasts (HDF), and human colorectal adenocarcinoma (CaCo-2) cell lines. The antimicrobial activity of methanolic extracts was tested on gram-negative (Escherichia coli and Pseudomonas aeuriginosa) and gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) using the in vitro minimum inhibition concentration method (MIC). Enzyme inhibition activity of R. acetosella methanol extract was measured spectrophotometrically against acetylcholinesterase (AChE) and glutathione S-transferase (GST) enzymes. Results: The findings showed that the major components of the methanol extract content were luteolin-7-O-glucoside (1.599 m/L), polydatin (91,024 m/L), and shikimic acid (0.773 m/L). It was determined that the extract and standard antioxidant (a-tocopherol) results in DPPH•, and ABTS• + tests performed to determine the antioxidant activity were close to each other, and this value was more effective than the standard antioxidant (α-tocopherol) in the CUPRAC test. These results suggested that the plant’s antioxidant potential was higher when compared with reference antioxidant compounds. It was determined that the methanol extract of R. acetosella had a weaker effect on the growth of the tested microorganisms than the antibiotics used as standard. The activity of the GST and AChE enzymes was found to be severely inhibited by the methanol extract of R. acetosella. Conclusion: Based on these findings, R. acetosella L. is a medicinal and commercially beneficial plant that warrants further investigation.
