Mardin Artuklu Üniversitesi Kurumsal Akademik Arşivi

DSpace@Artuklu, Mardin Artuklu Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.


Güncel Gönderiler

Determination of chemical composition and antioxidant, cytotoxic, antimicrobial, and enzyme inhibition activities of Rumex acetosella L. plant extract
(Springer, 2024) İrtegün Kandemir, Sevgi; Aktepe, Necmettin; Baran, Ayşe; Baran, Mehmet Fırat; Atalar, Mehmet Nuri; Keskin, Cumali; Karadağ, Musa; Eftekhari, Aziz; Alma, Mehmet Hakkı; Zor, Murat; Aliyeva, Immi; Khalilov, Rovshan
Purpose: The phenolic composition, antioxidant, antimicrobial activity, enzyme inhibition activity, and cytotoxic activity potentials of the plant Rumex acetosella L. (R. acetosella) were examined in this study. Materials and Methods: The chemical composition of R. acetosella methanol extract was identified by the LC–MS/MS method. The antioxidant activity was tested using β-carotene/linoleic acid, DPPH free radical scavenging, ABTS cation radical scavenging, CUPRAC reducing power, and metal chelating activity methods. The cytotoxic activity was determined by the MTT assay using human ovarian adenocarcinoma (Skov-3), glioblastoma (U87), human dermal fibroblasts (HDF), and human colorectal adenocarcinoma (CaCo-2) cell lines. The antimicrobial activity of methanolic extracts was tested on gram-negative (Escherichia coli and Pseudomonas aeuriginosa) and gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) using the in vitro minimum inhibition concentration method (MIC). Enzyme inhibition activity of R. acetosella methanol extract was measured spectrophotometrically against acetylcholinesterase (AChE) and glutathione S-transferase (GST) enzymes. Results: The findings showed that the major components of the methanol extract content were luteolin-7-O-glucoside (1.599 m/L), polydatin (91,024 m/L), and shikimic acid (0.773 m/L). It was determined that the extract and standard antioxidant (a-tocopherol) results in DPPH•, and ABTS• + tests performed to determine the antioxidant activity were close to each other, and this value was more effective than the standard antioxidant (α-tocopherol) in the CUPRAC test. These results suggested that the plant’s antioxidant potential was higher when compared with reference antioxidant compounds. It was determined that the methanol extract of R. acetosella had a weaker effect on the growth of the tested microorganisms than the antibiotics used as standard. The activity of the GST and AChE enzymes was found to be severely inhibited by the methanol extract of R. acetosella. Conclusion: Based on these findings, R. acetosella L. is a medicinal and commercially beneficial plant that warrants further investigation.
The quality problems at low irradiance in the grid-connected photovoltaic systems
(Springer, 2024) Adak, Süleyman; Cangi, Hasan
Solar photovoltaic (PV) energy is one of the most prominent topics that have attracted the attention of researchers in recent years. The use of solar energy is increasing rapidly in the world. Although using PV energy has various advantages, it has some disadvantages. Among these disadvantages, power factor (PF) and total harmonic distortion (THD) issues are discussed in this article. When solar PV systems are integrated into the grid, various power quality problems arise. In addition, due to low power quality and high harmonics, power system components overheat and start operating in undesirable regions; causes great damage. The magnitude of PF and THD is dependent on solar irradiation values. In order to determine how the power quality in the grid-connected solar system is affected by changes in solar irradiation (G), results for various irradiation situations are presented and analyzed. In addition, at low irradiance values, the amplitude of harmonic components and reactive power increases, whereas the power factor of the PV system decreases. Low power factor and high amplitude of harmonics cause the efficiency of the solar system to decrease. In this study, PF and THDI values were measured on a particular cloudy day for analysis. An analysis of the solar PV system was conducted using Matlab/simulation program to model the grid-connected PV system. Thus, the analytical expression of the PF and THDI, which are dependent on irradiation, was found with a new method by using the Statistical Package for the Social Sciences (SPSS) program and the curve fitting method. Obtaining the analytical expressions for both solar irradiation (G) and power factor (PF) used the SPSS program and also solar irradiation (G) and total harmonic distortion (THDI) used the MATLAB curve fitting method which contributed to the science comparing to the existing literature. It can be prevented the low power quality by using such these expressions at low solar irradiation cases.
Prognostic significance of the chemerin level in coronavirus disease 2019 patients
(Wolters Kluwer Health, Inc., 2024) Gökdemir, Gül Şahika; Gökdemir, Mehmet Tahir; Araç, Songül; Yokuş, Beran
Increased serum chemerin levels have been reported in several inflammatory diseases. Few studies have investigated the relationship between chemerin and clinical features of COVID-19. Thus, chemerin may modulate the development and progression of COVID-19. We compared the serum chemerin concentration between patients with and without SARS-CoV-2 infection and its association with the severity and prognosis of COVID-19 pneumonia. This is a prospective, single-center, cross-sectional study. We enrolled COVID-19 patients who presented to our tertiary hospital and healthy controls. The COVID-19 patients were conducted and the dates of symptom onset were recorded. After admission to the hospital and stabilization, blood samples were obtained for routine hemogram, biochemistry, and chemerin. The chemerin level was 37.93 ± 17.3 ng/mL in patients followed in the ICU, 29.41 ± 12.79 ng/mL in inpatients, 30.48 ± 10.86 ng/mL in outpatients, and 25.12 ± 9.82 ng/mL in healthy controls. The difference between patients treated in the ICU and healthy controls was significant (P < .001). The high-sensitivity C-reactive protein (hs-CRP), ferritin, procalcitonin (PCT), and D-dimer levels were significantly higher in the intensive care unit (ICU) group (P < .001). Moreover, the chemerin level of patients who died was significantly higher than that of those who survived (P < .001). The chemerin level was increased in COVID-19 patients and also increased with increasing disease severity. The chemerin level was higher in the COVID-19 patients than healthy controls and was significantly higher in patients who died compared to those who did not.
Assessment of preoperative anxiety and negative automatic thoughts in patients waiting for corneal transplantation
(Publishing Office of the University of Rzeszow, 2024) Tanrıverdi, Seher; Şen, Mehmet Ali; Genç, Hasan
Introduction and aim. In patients waiting for organ transplantation, increased waiting time can increase anxiety by creating negative automatic thoughts. The aim of this study is to examine the relationship between corneal transplant recipients' negative automatic thoughts and anxiety before organ transplantation. Material and methods. The population of this correlational descriptive study consisted of 108 patients waiting for cornea transplantation in the Eye Bank unit of a hospital in the south east region of Türkiye. The data were obtained from the patients presented to the ophthalmology clinic for transplantation between September and December 2022. A patient information form, the Negative Automatic Thoughts Scale, and the Trait Anxiety Scale were used to collect the data. Percentage distribution, arithmetic mean, logistic regression and correlation analysis were used in the data analysis. Results. It was determined that the mean score of the negative automatic thoughts of the transplant patients participating in the study was 100.69±47.83, and the trait anxiety mean score was 53.06±6.07. There was a positive relationship between negative automatic thoughts and trait anxiety at a moderate level, which was statistically significant (p<0.05, r=0.53). Conclusion. It was determined in the study that the patients' negative automatic thoughts and trait anxiety were high, and their anxiety increased as the negative automatic thoughts increased.
An Examination of the Effects of Propolis and Quercetin in a Rat Model of Streptozotocin-Induced Diabetic Peripheral Neuropathy
(Multidisciplinary Digital Publishing Institute (MDPI), 2024) Türedi, Sibel; Çelik, Hakim; Dağlı, Şeyda Nur; Taşkın, Seyhan; Şeker, Uğur; Deniz, Mustafa
The purpose of this study was to reveal the combined effects of propolis (P) and quercetin (Q) against diabetic peripheral neuropathy developing with streptozotocin-induced diabetes in rats. Sixty-four adult male rats were divided into eight equal groups: control, P (100 mg/kg/day), Q (100 mg/kg/day), P + Q (100 mg/day for both), diabetes mellitus (DM) (single-dose 60 mg/kg streptozotocin), DM + P, DM + Q, and DM + P + Q. The rats were sacrificed, and blood and sciatic nerve tissues were collected. Blood glucose and malondialdehyde (MDA) levels increased, while IL-6 and total antioxidant status decreased in the DM group (p = 0.016 and p = 0.047, respectively). Ultrastructural findings showed degeneration of the axon and myelin sheath. The apoptotic index (AI %), TNF-α, and IL-1β immunopositivity increased significantly in the DM group (p < 0.001). Morphological structures approaching those of the controls were observed in the DM + P, DM + Q, and DM + P + Q groups. Morphometric measurements increased markedly in all treatment groups (p < 0.001), while blood glucose and MDA levels, AI (%), TNF-α, and IL-1β immunopositivity decreased. In conclusion, the combined effects of propolis and quercetin in diabetic neuropathy may provide optimal morphological protection with neuroprotective effects by reducing hyperglycemia, and these may represent a key alternative supplement in regenerative medicine.