Mardin Artuklu Üniversitesi Kurumsal Akademik Arşivi
DSpace@Artuklu, Mardin Artuklu Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Morphological, physiological, molecular, and pathogenic insights into the characterization of Phytophthora polonica from a novel host, hazelnut (Corylus avellana)
(Elsevier, 2024) Türkkan, Muharrem; Özer, Göksel; Derviş, Sibel
Hazelnuts, constituting a significant global crop, hold paramount importance in Türkiye, contributing to approximately 71.14 % of the world's hazelnut cultivation area. In the summer of 2023, hazelnut trees in two orchards situated in the Altınordu district of Ordu province, within the Black Sea region of Türkiye, the largest producer and exporter of hazelnuts, exhibited symptoms of decline associated with root rot. Phytophthora sp. was consistently isolated from necrotic taproots, initiating an in-depth study to discern the causal agent behind the observed hazelnut decline. The species was identified as P. polonica by its distinctive morphological traits, including homothallic characteristics, amphigynous or paragynous antheridia, long nonbranching sporangiophores, and nonpapillate sporangia with internal proliferation. Multiple genetic markers (ITS, tub2, and COI) facilitated a clear differentiation of P. polonica from other Phytophthora species within Clade 9, supporting its classification within Subclade 9b. This investigation also evaluated the impact of diverse nutrient media (CA, V8A, and CMA), temperatures, and pH levels on the mycelial growth of P. polonica HPp-1 and HPp-2 isolates. The optimal conditions for maximal mycelial growth were determined through the D-optimal design of the Response Surface Method, revealing the significant influence of all factors on mycelial growth. The identified optimal conditions were at 26.09 °C, pH 5.12, with CMA as the nutrient medium. Validation experiments conducted under these optimal conditions unveiled mycelial growth of 7.24 ± 0.15 mm day−1 and 6.81 ± 0.09 mm day−1 for P. polonica HPp-1 and HPp-2 isolates, respectively, with an error of less than 5 %. Pathogenicity assessments confirmed P. polonica's virulence on hazelnuts, with distinct lesion development observed in twig inoculation, cut stem segments, and foliar tests. While no statistically significant difference was noted in lesion areas between HPp-1 and HPp-2 isolates in twig and stem segment assays, a statistical difference in leaf lesion areas (19.96 ± 2.04 cm2 and 9.16 ± 3.43 cm2) emerged in foliar tests after only a 5-day incubation period, indicating their high susceptibility to the pathogen. This study is the first to report P. polonica as a hazelnut pathogen in Türkiye and around the world, highlighting the previously non-existent threat of Phytophthora root rot in hazelnuts, given the substantial lack of scientifically documented cases related to hazelnut root rot diseases. The quadratic model design employed in physiological analyses is reliable for optimizing mycelial growth and can serve as a guiding framework for similar investigations.
Bronchiectasis in Türkiye: Data from a Multicenter Registry (Turkish Adult Bronchiectasis Database)
(GALENOS PUBL HOUSE, 2024) Çakır Edis, Ebru; Çilli, Aykut; Kızılırmak, Deniz; Şakar Coşkun, Ayşin; Güler, Nurcan; Çiçek, Sedat; Sevinç, Can; Çoban Ağca, Meltem; Gülmez, İnci; Çağlayan, Benan; Kabak, Mehmet; Özgün Niksarlıoğlu, Elif Yelda
Background: Bronchiectasis is a chronic lung disease characterized by permanent bronchial wall dilatation. Although it has been known as an orphan disease, it has recently gained attention because of registry-based studies and drug research. Aims: We aimed to use a multicenter database to analyze and compare data regarding the etiology, associated comorbidities, microbiological characteristics, and preventive strategies of bronchiectasis in Türkiye to those of other countries. Study Design: A multicenter prospective cohort study. Methods: The multicenter, prospective cohort study was conducted between March 2019 and January 2022 using the Turkish Adult Bronchiectasis Database, in which 25 centers in Türkiye participated. Patients aged > 18 years who presented with respiratory symptoms such as cough, sputum, and dyspnea and were diagnosed with non-cystic fibrosis bronchiectasis using computed tomography were included in the study. Demographic information, etiologies, comorbidities, pulmonary functions, and microbiological, radiological, and clinical data were collected from the patients. Results: Of the 1,035 study participants, 518 (50%) were females. The mean age of the patients was 56.1 ± 16.1 years. The underlying etiology was detected in 565 (54.6%) patients. While postinfectious origin was the most common cause of bronchiectasis (39.5%), tuberculosis was identified in 11.3% of the patients. An additional comorbidity was detected in 688 (66.5%) patients. The most common comorbidity was cardiovascular disease, and chronic obstructive pulmonary disease (COPD) and bronchiectasis was identified in 19.5% of the patients. The most commonly detected microbiological agent was Pseudomonas aeruginosa (29.4%). Inhaled corticosteroids (ICS) were used in 70.1% of the patients, and the frequency of exacerbations in the last year was significantly higher in patients using ICS than in nonusers (p < 0.0001). Age [odds ratio (OR): 1.028; 95% confidence interval (CI): 1.005-1.051], cachexia (OR: 4.774; 95% CI: 2,054-11,097), high modified medical research council dyspnea scale score (OR: 1,952; 95% CI: 1,459-2,611), presence of chronic renal failure (OR: 4,172; 95% CI: 1,249-13,938) and use of inhaled steroids (OR: 2,587; 95% CI: 1,098-6,098) were significant risk factors for mortality. Mortality rates were higher in patients with COPD than in those with no COPD (21.7-9.1%, p = 0.016). Patients with bronchiectasis and COPD exhibited more frequent exacerbations, exacerbation-related hospitalizations, and hospitalization in the intensive care unit in the previous year than patients without COPD. Conclusion: This is the first multicenter study of bronchiectasis in Türkiye. The study results will provide important data that can guide the development of health policies in Türkiye on issues such as infection control, vaccination, and the unnecessary use of antibiotics and steroids.
The impact of some animal products on agricultural gross domestic product in Türkiye: A time series analysis
(REVISTA BRASILEIRA ZOOTECNIA BRAZILIAN JOURNAL ANIMAL SCI, 2024) Acıbuca, Veysi
The relationship between animal products and agricultural gross domestic product (AGDP) in Turkiye was investigated in this study. We used data of eight animal products (cow milk, sheep milk, beef, mutton, poultry meat, eggs, wool, and honey) from 1980 to 2020. After checking the stationarity of the series by the Augmented Dickey-Fuller (ADF) test, the Johansen cointegration test was used to establish the existence of a long-term relationship between animal products and AGDP, and the results were interpreted using The Fully Modified Ordinary Least Squares (FMOLS) analysis. According to the findings, honey, beef, poultry meat, mutton, eggs, and wool had a positive and significant relationship with AGDP in Turkiye, whereas sheep milk and cow milk and AGDP was not significant. The total effect of the examined animal products on AGDP was 0.61%. The results showed that wool was the most important contributor to AGDP among the products analyzed. Therefore, it is suggested that policymakers develop funding strategies to expand the production of these products.
Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study
(Springer, 2024) Karcı, Bilge; Savaş, Hasan Basri
Background: This study aimed to assess and compare the concentrations of growth factors, white blood cells (WBCs), and platelets in injectable platelet-rich fibrin (i-PRF) derived from people with healthy periodontal conditions and those with chronic periodontitis.
Methods: Venous blood samples were obtained from 30 patients diagnosed with chronic periodontitis (test group) and 30 participants with healthy periodontal conditions (control group). The i-PRF was then acquired from centrifuged blood. The growth factors (VEGF, IGF-1, TGF-β1, PDGF-BB and EGF) released from the i-PRF samples were compared between groups with ELISA testing. The amounts of WBCs and platelets were also compared.
Results: No significant differences in the concentrations of growth factors were found between the groups (the mean values for the control and test groups were, respectively: IGF: 38.82, 42.46; PDGF: 414.25, 466.28; VEGF: 375.69, 412.18; TGF-β1: 21.50, 26.21; EGF: 138.62, 154.82). The test group exhibited a significantly higher WBC count than the control group (8.80 vs. 6.60, respectively). However, the platelet count did not show a statistically significant difference between the groups (control group 242.0 vs. test group 262.50). No significant correlation was observed between WBC count and growth factor level in either group.
Conclusions: The growth factor levels in i-PRFs did not exhibit significant difference between the two groups. This suggests that the levels of these growth factors may be unaffected by the periodontal disease.
Thirteen-year surveillance results of acute flaccid paralysis cases in Southeast Turkey and the effect of refugee movements on surveillance results
(National Institute of Public Health, 2024) Özgün, Nezir; Kubat, Gülnaz; Turan, Birgül; Özgün, Mert; Toktaş, İzzettin; Korukluoğlu, Gülay
Objective: Acute flaccid paralysis (AFP) is a major neurological problem. Turkey has accepted over 4 million refugees since 2011 due to the wars in neighbouring countries. In the long term, refugees can have adverse effects on the limited resources of health, sanitation, water supply, foodstuff, and shelter services of host countries, precipitating the transmission and spread of enteroviruses causing AFP. This study examines the 13-year surveillance and incidence of AFP cases in southeast Turkey, and questions possible impact of refugee movements on these parameters, comparing the periods before (2007-2010) and after (2011-2019) 2011, when the refugee movements emerged.
Methods: The records of cases reported from southeast part of Turkey with suspected AFP between January 2007 and December 2019 were reviewed retrospectively.
Results: Of the patients, 121 (58.5%) were male. Mean age was 80.36 ± 46.67 months. Eighty-five (41.1%) were aged 60 months or younger. The number of patients under 60 months increased significantly after 2011. Mean incidence was calculated as 0.88 cases/100,000 person years versus 1.58 cases/100,000 person years in the period before and after 2011, respectively. Guillain-Barré syndrome (GBS) was the most common cause of AFP in both periods. As of 2011, however, the incidence of acute transverse myelitis increased approximately 4 times and GBS decreased proportionally. Non-polio enteroviruses were the most frequent isolates, detected from 9.1% of stool samples.
Conclusion: Although refugee movements appear to may have adverse effects on AFP incidence and surveillance outcomes, larger studies involving the whole country, particularly at places where no refugees settled, are needed to achieve more conclusive evidence.
