Estradiol and ascorbic acid alleviate malathion-induced lung damage in albino Wistar rats: A histopathological study

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dc.authorid0000-0002-2832-8409en_US
dc.authorscopusid57214259186en_US
dc.authorwosidAAK-7940-2021en_US
dc.contributor.authorAlhilal, Mohammad
dc.contributor.authorSalem, Mahmoud Elsayed Mohamed
dc.date.accessioned2024-03-05T07:25:46Z
dc.date.available2024-03-05T07:25:46Z
dc.date.issued2024en_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümüen_US
dc.description.abstractAim: To assess the modulatory role ofestradiol and ascorbic acidin malathion-induced pulmonary toxicity in albinoWistarrats. Methods: A total of twenty albino Wistar rats were randomly divided into four groups; the control group (group 1) was given corn oil alone, the test group (group 2) received a daily dose of malathion 20 mg/kg in corn oil, treatment group A (group 3) was administered a daily dose of malathion 20 mg/kg in corn oil plus estradiol 40 μg/100 g (gram), and treatment group B (group 4) received a daily dose of malathion 20 mg/kg in corn oil plus ascorbic acid 100 mg/kg. Experimental rats were administered once daily for four weeks. The lungs were examined histopathologically using two staining methods (Hematoxylin and Eosin, Masson Trichrome).Results: There were significant reductions in degeneration, interstitial pneumonia and interstitial fibrosis for group 3 (treatment group A) compared to group 2 (test group) (p<0.05). These reductions were more statisticallysignificant for group 4 (treatment group B) compared to group 2 (test group) (p<0.01).Therefore, the damage was less pronounced and injury severity was moderate in group 3 treated with estradiol. Group 4, with ascorbic acid, showed the mostimprovement with significant tissue repair under microscopic examination andmild injury compared to group 3.Conclusions: The results of our present study suggest that both estradiol and ascorbic acid have clear protective effects against malathion-induced lung injury. However, ascorbic acid exhibited more pronounced protective effects compared to estradiol. With more comprehensive studies, the positive effects of ascorbic acid and estradiol can be used to prevent lung damage in individuals exposed to malathion.en_US
dc.identifier.citationAlhilal, M., & Salem, M. E. M. (2024). Estradiol and ascorbic acid alleviate malathion-induced lung damage in albino Wistar rats: A histopathological study. EXPERIMENTAL BIOMEDICAL RESEARCH, 7(1), 9–18. https://doi.org/10.30714/j-ebr.2024.203en_US
dc.identifier.doi10.30714/j-ebr.2024.203en_US
dc.identifier.endpage18en_US
dc.identifier.issn2618-6454
dc.identifier.issue1en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12514/5831
dc.identifier.volume7en_US
dc.institutionauthorAlhilal, Mohammad
dc.institutionauthorSalem, Mahmoud Elsayed Mohamed
dc.language.isoenen_US
dc.relation.ispartofExperimental Biomedical Research Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAscorbic aciden_US
dc.subjectestradiolen_US
dc.subjectinflammationen_US
dc.subjectlung damageen_US
dc.subjectmalathionen_US
dc.subjectratsen_US
dc.titleEstradiol and ascorbic acid alleviate malathion-induced lung damage in albino Wistar rats: A histopathological studyen_US
dc.typeArticleen_US

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