EFFECT OF METFORMIN ON MUSCLE ATROPHY IN EXPERIMENTAL DIABETIC RATS
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Tarih
2023
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Although first-line biguanide metformin is frequently administered to T2DM patients, the effects of long-term
use on muscle are unknown. This study aimed to examine the effect of metformin-treated diabetes on muscle atrophy in experimental
diabetic rats.
Materials and methods: Twenty-one Wistar albino male rats in 3 groups were included in our research. Insulin resistance
HOMA-IR, mTOR, and Myostatin levels and gastrocnemius weight were measured.
Results: Myostatin level was significantly higher in the non-medicated diabetes group than in the healthy control group
(p<0.001). Moreover, myostatin level was significantly lower in the metformin group (p=0.001). The weight of gastrocnemius was
significantly lower in both the metformin-treated and non-metformin-treated diabetic groups compared to the control group (p<0.001
for both groups). Moreover, the gastrocnemius weight was significantly higher in the metformin group than in the non-medicated group
(p=0.004). The HOME-IR level had a significantly negative correlation with the mTOR level (R=-0.783; P<0.001) and a positive
correlation with the myostatin level (R=0.622; P=0.003).
Conclusion: Our evidence and data support that metformin may be effective in preventing muscle wasting. To conclude, this
study showed that metformin has anti-atrophic effects on muscles in diabetes and that metformin can prevent muscle mass loss.
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WoS Q Değeri
Q4
