Clınıcal Sıgnıfıcance of HDL-C Values And Routıne Parameters Of Inflammatıon Such As Hs-Crp, Lenfocyte And Neutrofıl Ratıos In Covıd-19 Patıents
| dc.authorid | 0000-0002-8691-1504 | en_US |
| dc.contributor.author | Gökdemir, Gül Şahika | |
| dc.contributor.author | Nas, Cemal | |
| dc.date.accessioned | 2023-12-21T08:53:53Z | |
| dc.date.available | 2023-12-21T08:53:53Z | |
| dc.date.issued | 2023 | en_US |
| dc.department | MAÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
| dc.description.abstract | Objective: The study aimed to evaluate the prognostic significance of high-density lipoprotein cholesterol (HDL-C) levels, alongside markers including the neutrophil/HDL-C ratio (NHR) and lymphocyte/HDL-C ratio (LHR), on the mortality of COVID-19 patients. It also examined the potential clinical application of these biomarkers in the management of future healthcare crises, despite the end of the COVID-19 pandemic. Materials and Methods: Patients diagnosed with COVID-19 were retrospectively analysed between March 2020 and August 2022. A total of 367 patients were categorised into two groups: survivors (group 2) and non-survivors (group 1). Patient demographics, biochemical and haematological parameters obtained from blood samples, high-sensitivity C-reactive protein (hs-CRP), neutrophil-to-lymphocyte ratio (NLR), monocyte/HDL-C ratio (MHR), NHR, LHR, platelet/HDL-C ratio (PHR) were calculated. Patient data were analysed using SPSS 26 and statistical differences of P<0.05 were considered significant. Results: Among the patients analyzed in the study, the living group constituted 89.9% of individuals, while the deceased group represented 10.1%. The neutrophil levels were significantly higher in the deceased group, and NLR and NHR values were statistically significant (P<0.001 and P=0.001, respectively). There was no significant difference in HDL-C levels. Moreover, no significant differences in LHR, MHR, and PHR levels were observed between groups. The hs-CRP levels were significantly higher in the deceased (P<0.001). Correlation analysis indicated a negative correlation between HDL-C and LHR and NHR, and significant correlations were found for other markers. ROC analysis showed that LHR and NHR were significant in discriminating deceased patients. Conclusion: Biochemical and haematological parameters, especially markers such as NLR and NHR, can potentially be used to assess the risk of death in COVID-19 patients. These markers may be valuable in predicting the prognosis of patients and could be used in future similar health crises. | en_US |
| dc.identifier.citation | GÖKDEMİR GŞ, NAS C. Clınıcal Sıgnıfıcance of HDL-C Values And Routıne Parameters Of Inflammatıon Such As Hs-Crp, Lenfocyte And Neutrofıl Ratıos In Covıd-19 Patıents Ege Klin Tıp Derg 2023;61 (3): 252-258 | en_US |
| dc.identifier.endpage | 258 | en_US |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.startpage | 252 | en_US |
| dc.identifier.uri | chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.egeklinikleritipdergisi.com/wp-content/uploads/2023/12/ARALIK-2023.pdf | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12514/5104 | |
| dc.identifier.volume | 61 | en_US |
| dc.institutionauthor | Gökdemir, Gül Şahika | |
| dc.language.iso | en | en_US |
| dc.publisher | İZMİR ATATÜRK EĞİTİM HASTANESİ TIP DERGİSİ | en_US |
| dc.relation.ispartof | EGE KLİNİKLERİ TIP DERGİSİ | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | COVID-19, High-density lipoprotein (HDL-C), Neutrophil/HDL-C ratio, Lymphocyte/HDL-C ratio | en_US |
| dc.title | Clınıcal Sıgnıfıcance of HDL-C Values And Routıne Parameters Of Inflammatıon Such As Hs-Crp, Lenfocyte And Neutrofıl Ratıos In Covıd-19 Patıents | en_US |
| dc.title.alternative | Covid-19 Hastalarında HDL-K Değerinin Rutin İnflamasyon Parametreleri Olan h-CRP,Lenfosit ve Nötrofil Oranlarının Klinik Önemi | en_US |
| dc.type | Article | en_US |
