Is There a Relationship Between First-Trimester Aneuploidy Screening Serum Biomarker Values and Nuchal Translucency Measurements and the Development of Retinopathy of Prematurity (ROP) in Premature Infants?

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dc.authoridhttps://orcid.org/0000-0001-8759-4507en_US
dc.date.accessioned2023-12-22T12:34:52Z
dc.date.available2023-12-22T12:34:52Z
dc.date.issued10/13/2023en_US
dc.departmentMAÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractAbstract Purpose The purpose of this study is the evaluation of serum biomarker and nuchal translucency (NT) values measured during first-trimester aneuploidy screening in terms of the development of retinopathy of prematurity (ROP) in premature infants and investigation of whether the development of ROP is associated with these parameters. Methods In this retrospective cohort study, 3,750 premature infants who underwent ROP screening from 2016 to 2021 were identified from the hospital medical record system. Among 2,130 premature babies screened for firsttrimester aneuploidy, 166 babies whose mothers had single pregnancies were screened by the same method and showed the same clinical course in both eyes were included in the study. The infants were divided into two groups according to the presence of ROP, and those with ROP were further evaluated in two groups according to the presence of proliferation. The groups were compared in terms of the serum values of human chorionic gonadotropin and pregnancy-associated plasma protein A, among aneuploidy screening biomarkers, and NT measurements. Results There was no significant difference in the evaluated serum biomarker values and NT measurements between the ROP and non-ROP groups or between the proliferative ROP, non-proliferative ROP, and non-ROP groups. Conclusion Our results showed that first-trimester aneuploidy screening serum biomarker values and NT measurements were not associated with the development of ROP in premature infants.en_US
dc.identifier.citationKüçük M, Savaş H, Suren E, et al. (October 13, 2023) Is There a Relationship Between First-Trimester Aneuploidy Screening Serum Biomarker Values and Nuchal Translucency Measurements and the Development of Retinopathy of Prematurity (ROP) in Premature Infants?. Cureus 15(10): e46969. DOI 10.7759/cureus.46969en_US
dc.identifier.doi10.7759/cureus.46969en_US
dc.identifier.endpagee46969en_US
dc.identifier.issue10en_US
dc.identifier.startpagee46969en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12514/5154
dc.identifier.volume15en_US
dc.institutionauthorSavaÅŸ, Hasan Basri
dc.language.isoenen_US
dc.publisherNatureen_US
dc.relation.ispartofCureusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectfirst-trimester aneuploidy screening, nuchal translucency, pregnancy-associated plasma protein a, human chorionic gonadotropin, retinopathy of prematurityen_US
dc.titleIs There a Relationship Between First-Trimester Aneuploidy Screening Serum Biomarker Values and Nuchal Translucency Measurements and the Development of Retinopathy of Prematurity (ROP) in Premature Infants?en_US
dc.typeArticleen_US

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