Predicting the mortality in patients with carotid artery stenosis by monocyte to high density lipoprotein ratio

Günlü, Serhat

Predicting the mortality in patients with carotid artery stenosis by monocyte to high density lipoprotein ratio

dc.authorid	0000-0001-6985-6112	en_US
dc.contributor.author	Günlü, Serhat
dc.date.accessioned	2023-12-11T12:58:41Z
dc.date.available	2023-12-11T12:58:41Z
dc.date.issued	2023	en_US
dc.department	MAÜ, Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı	en_US
dc.description.abstract	Introduction: Background: Monocytes, which produce a variety of cytokines and molecules, interact with platelets and endothelial cells, causing inflammatory and thrombotic pathways to become worse. Macrophage migration and oxidation of low-density lipoprotein cholesterol molecules are both inhibited by high-density lipoprotein cholesterol (HDL-C). HDL-C neutralizes monocytes' pro-inflammatory and pro-oxidant effects through several mechanisms. As a result, characteristics like the monocyte to HDL-C ratio (MHR) may reveal a patient's inflammatory status. Objective: The development of carotid artery stenosis (CAS) is influenced by inflammation, oxidative stress, and endothelial dysfunction. Recent research suggests that inflammatory biomarkers are important for assessing mortality in carotid artery stenosis. This study aims to determine the association between MHR and mortality after carotid artery stenting. Tools and Method: We enrolled 260 patients with CAS who underwent carotid artery stenting between 2019 and 2021. MHR was calculated using the formula: the monocyte value dividing by the high-density lipoprotein cholesterol value. According to 30-day mortality, the patients were divided into two groups; surviving and non-surviving. Monocyte counts, HDL-C, and MHR values were compared between the groups. Results: The patient group had significantly higher monocyte counts and lower HDL levels than the control group, resulting in higher MHR values. In addition, non-surviving patients had a higher monocyte count and MHR value, as well as a lower HDL-C level (p<0.001). In patients with CAS, the MHR value was also found to be a significant independent determinant of 30-day mortality (p<0.001). MHR had the optimum cut-off value of 17.52 with 78.3% sensitivity and 83.4% specificity (AUC:0.724, p<0.001) for predicting 30-day mortality in patients with CAS. Comparison of the monocyte count, HDL level, and MHR value according to the mortality within the 30 days. Non-surviving group n=48 Surviving group n=212 P-values Monocyte (x109 µL) 915.42±53.21 524.03±9.98 <0.001 HDL-C (mg/dL) 37.03±1.16 46.22±0.9 <0.001 MHR 18.86±5.25 12.21±2.21 <0.001 Values are presented as mean ± SD and median [interquartile range]. HDL-C; high-density lipoprotein cholesterol, MHR; monocyte to high-density lipoprotein ratio. Discussion: Conclusion: In patients with CAS, a high MHR value was found to be an independent predictor of 30-day mortality.	en_US
dc.identifier.uri	https://hdl.handle.net/20.500.12514/4545
dc.institutionauthor	Günlü, Serhat
dc.language.iso	en	en_US
dc.relation.ispartof	Advanced Stroke and Peripheral Intervention Course (ASPIC 2023)	en_US
dc.relation.publicationcategory	Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı	en_US
dc.rights	info:eu-repo/semantics/openAccess	en_US
dc.subject	Carotid artery stenosis, monocyte, high-density lipoprotein.	en_US
dc.title	Predicting the mortality in patients with carotid artery stenosis by monocyte to high density lipoprotein ratio	en_US
dc.type	Presentation	en_US