Importance of curcumin effect and asprosin level on glucose metabolism in diabetic rats

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dc.authorid0000-0002-8691-1504en_US
dc.contributor.authorGökdemir, Gül Şahika
dc.contributor.authorGökdemir, Mehmet Tahir
dc.contributor.authorTaşdemir, Ezel
dc.contributor.authorBeran, Yokuş
dc.contributor.authorBaylan,Mukadder
dc.date.accessioned2023-12-30T20:09:42Z
dc.date.available2023-12-30T20:09:42Z
dc.date.issued2023en_US
dc.departmentMAÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.description.abstractAsprosin is a new hormone secreted mainly from white adipose tissue. It may be associated with the pathogenesis of obesity, diabetes and some metabolic diseases. The changes in plasma asprosin levels of experimental diabetic rats and the relation of these changes with liver glucose metabolism and some diabetes parameters were investigated, and the effects of metformin, gliclazide or curcumin treatment on plasma asprosin levels were tried. The study was designed as an animal model in diabetic rats The albino rats were divided into five groups. To induce diabetes, a single dose of STZ was injected intraperitoneally. Diabetics rats were treated intragastrically with metformin (D+Metformin group), gliclazide (D+Giliclazide group) or 20 curcumin (D+Curcumin group) for eight weeks. Fasting blood glucose, insulin levels and other parameters were measured. Plasma asporsin levels of untreated diabetic rats increased significantly (P<.001). Although the plasma asprosin levels of diabetic rats treated with the rugs were significantly lower (P<.001). Fasting blood glucose levels of diabetic rats treated with the drugs were found to be remarkably lower than the diabetic control values (P<.001, respectively). There was no significant difference in the insulin levels and HOMAIR between these three groups. Curcumin treatment provides significant improvements in plasma asprosin level and diabetes parameters. The increase in plasma asprosin level in diabetic rats may be one of the main reasons that facilitate the development of the disease or is responsible for its pathogenesis. Our findings support the idea that curcumin may be an important treatment option for diabetes.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12514/5347
dc.institutionauthorGökdemir, Gül Şahika
dc.language.isoenen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleImportance of curcumin effect and asprosin level on glucose metabolism in diabetic ratsen_US
dc.typeArticleen_US

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