Prognostic significance of the chemerin level in coronavirus disease 2019 patients

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dc.contributor.authorGökdemir, Gül Şahika
dc.contributor.authorGökdemir, Mehmet Tahir
dc.contributor.authorAraç, Songül
dc.contributor.authorYokuş, Beran
dc.date.accessioned2024-04-15T10:45:32Z
dc.date.available2024-04-15T10:45:32Z
dc.date.issued2024
dc.departmentMAÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractIncreased serum chemerin levels have been reported in several inflammatory diseases. Few studies have investigated the relationship between chemerin and clinical features of COVID-19. Thus, chemerin may modulate the development and progression of COVID-19. We compared the serum chemerin concentration between patients with and without SARS-CoV-2 infection and its association with the severity and prognosis of COVID-19 pneumonia. This is a prospective, single-center, cross-sectional study. We enrolled COVID-19 patients who presented to our tertiary hospital and healthy controls. The COVID-19 patients were conducted and the dates of symptom onset were recorded. After admission to the hospital and stabilization, blood samples were obtained for routine hemogram, biochemistry, and chemerin. The chemerin level was 37.93 ± 17.3 ng/mL in patients followed in the ICU, 29.41 ± 12.79 ng/mL in inpatients, 30.48 ± 10.86 ng/mL in outpatients, and 25.12 ± 9.82 ng/mL in healthy controls. The difference between patients treated in the ICU and healthy controls was significant (P < .001). The high-sensitivity C-reactive protein (hs-CRP), ferritin, procalcitonin (PCT), and D-dimer levels were significantly higher in the intensive care unit (ICU) group (P < .001). Moreover, the chemerin level of patients who died was significantly higher than that of those who survived (P < .001). The chemerin level was increased in COVID-19 patients and also increased with increasing disease severity. The chemerin level was higher in the COVID-19 patients than healthy controls and was significantly higher in patients who died compared to those who did not.
dc.identifier.citationGokdemir, Gül Şahika PhDa,*; Gokdemir, Mehmet Tahir MDb; Araç, Songül MDc; Yokuş, Beran PhDd. Prognostic significance of the chemerin level in coronavirus disease 2019 patients. Medicine 103(14):p e37743, April 05, 2024. | DOI: 10.1097/MD.0000000000037743
dc.identifier.doi10.1097/MD.0000000000037743
dc.identifier.endpage1974
dc.identifier.issue14
dc.identifier.pmid38579052
dc.identifier.scopusqualityN/A
dc.identifier.startpage1955
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000037743
dc.identifier.urihttps://hdl.handle.net/20.500.12514/5859
dc.identifier.volume103
dc.identifier.wosqualityN/A
dc.institutionauthorGökdemir, Gül Şahika
dc.institutionauthorGökdemir, Mehmet Tahir
dc.institutionauthorid0000-0002-8691-1504
dc.institutionauthorid0000-0002-5546-9653
dc.language.isoen
dc.publisherWolters Kluwer Health, Inc.
dc.relation.ispartofMedicine (Baltimore)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChemerin
dc.subjectCoronavirus disease 2019
dc.subjectIntensive care unit
dc.subjectOutpatient
dc.titlePrognostic significance of the chemerin level in coronavirus disease 2019 patients

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