Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice
Yükleniyor...
Dosyalar
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Opioids have indispensable roles in pain management. A strong link exists between
opioid use and memory impairments, mainly with continuous use. This study investigated
the effects of two opioid drugs, meperidine and fentanyl, on emotional memory functions,
brain morphology, and the possible protective effects of low-dose ketamine in mice.
Materials and Methods: A passive avoidance (PA) test was used to measure emotional
memory functions following seven daily drug applications in 48 male Balb/C mice (30-35
g). Meperidine (10 mg/kg), fentanyl (0.3 mg/kg), ketamine (5 mg/kg), and combinations
of ketamine with the opioids were intraperitoneally injected daily. No drugs were utilized
during the testing days. Brain tissues were obtained after sacrification and put into diluted
formalin solution for histopathological analysis.
Results: Transfer latencies of the meperidine and fentanyl-treated groups in the PA
test were lower than in the vehicle-treated group (p<0.01, p<0.05, respectively). Ketamine combined with meperidine had higher latencies than in the meperidine-treated
group (p<0.05). The augmenting effects of ketamine were evident against fentanyl and
meperidine-induced neurotoxicity as morphologic alterations were reduced.
Conclusion: Low-dose ketamine may fend against opioid-induced neurotoxicity and emotional memory impairments, especially against meperidine, which can be a practical alternative to fentanyl in clinical settings.
Açıklama
Anahtar Kelimeler
Ketamine, Opioids, Memory impairments, Passive avoidance, Brain morphology
Kaynak
Annals of Medical Research
WoS Q Değeri
Scopus Q Değeri
Cilt
30
Sayı
11
Künye
Uyar E, Seker U, Ozhan O, Acikgul MB, Colak M, Izci SF, Parlakpinar H. Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice.
