Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice

Basit Öğe Kaydı
dc.authoridhttps://orcid.org/0000-0002-1693-6378en_US
dc.authorscopusidhttps://www.scopus.com/authid/detail.uri?authorId=55910059600en_US
dc.authorwosidhttps://www.webofscience.com/wos/author/record/48480en_US
dc.contributor.authorUyar, Emre; Şeker, Uğur; Özhan, Onural; Açıkgül, Muhammet Burak; Çolak, Mehmet; İzci, Sevde Feyza; Parlakpınar, Hakan
dc.date.accessioned2023-12-18T09:43:03Z
dc.date.available2023-12-18T09:43:03Z
dc.date.issued2023en_US
dc.departmentMAÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractAim: Opioids have indispensable roles in pain management. A strong link exists between opioid use and memory impairments, mainly with continuous use. This study investigated the effects of two opioid drugs, meperidine and fentanyl, on emotional memory functions, brain morphology, and the possible protective effects of low-dose ketamine in mice. Materials and Methods: A passive avoidance (PA) test was used to measure emotional memory functions following seven daily drug applications in 48 male Balb/C mice (30-35 g). Meperidine (10 mg/kg), fentanyl (0.3 mg/kg), ketamine (5 mg/kg), and combinations of ketamine with the opioids were intraperitoneally injected daily. No drugs were utilized during the testing days. Brain tissues were obtained after sacrification and put into diluted formalin solution for histopathological analysis. Results: Transfer latencies of the meperidine and fentanyl-treated groups in the PA test were lower than in the vehicle-treated group (p<0.01, p<0.05, respectively). Ketamine combined with meperidine had higher latencies than in the meperidine-treated group (p<0.05). The augmenting effects of ketamine were evident against fentanyl and meperidine-induced neurotoxicity as morphologic alterations were reduced. Conclusion: Low-dose ketamine may fend against opioid-induced neurotoxicity and emotional memory impairments, especially against meperidine, which can be a practical alternative to fentanyl in clinical settings.en_US
dc.description.sponsorshipİnönü Üniversitesi BAP Koordinatörlüğü Proje No: TSA-2022-2882.en_US
dc.identifier.citationUyar E, Seker U, Ozhan O, Acikgul MB, Colak M, Izci SF, Parlakpinar H. Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice.en_US
dc.identifier.doi10.5455/annalsmedres.2023.09.241en_US
dc.identifier.endpage1441en_US
dc.identifier.issn2636-7688
dc.identifier.issue11en_US
dc.identifier.startpage1437en_US
dc.identifier.trdizinid1209348en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2023.09.241
dc.identifier.urihttps://hdl.handle.net/20.500.12514/4938
dc.identifier.volume30en_US
dc.institutionauthorŞeker, Uğur
dc.language.isoenen_US
dc.publisherİnönü Üniversitesi Tıp Fakültesien_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Başka Kurum Yazarıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKetamineen_US
dc.subjectOpioidsen_US
dc.subjectMemory impairmentsen_US
dc.subjectPassive avoidanceen_US
dc.subjectBrain morphologyen_US
dc.titleAmeliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in miceen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
134-1693834615.pdf
Boyut:
2.37 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Full text article
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Histoloji ve Embriyoloji Anabilim Dalı Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu