Carbamazepine-induced renal toxicity may be associated with oxidative stress and apoptosis in male rat
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Online
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Carbamazepine (CBZ) is the antiepileptic drug used in epilepsy and some psychiatric disorders. Besides its widely used, many adverse effects have been reported including hematotoxicity, hepatotoxicity, endocrine disorders, and testicular damages due to oxidative stress. However, the role of CBZ on renal toxicity is not fully known. In this study, we attempted to explain the connected mechanisms by focusing on the metabolism of CBZ-induced renal toxicity in rats. Twenty male Wistar-Albino rats were randomized into 2 groups (n = 10); control (1 mL/day distilled water, orally) and CBZ (25 mg/kg/day CBZ, orally) groups. After 60 days, TAS (total oxidant status) and TOS (total oxidant status) levels, histopathological features, some genes involved in apoptosis, 8-hydroxy-2-deoxyguanosine (8-OHdG) activity, and apoptotic cells were assessed of kidney tissue. The oxidative stress index (OSI) was measured from TAS and TOS levels. TOS levels and OSI significantly increased, while TAS levels decreased in the CBZ group relative to the control group. Histopathological observations, Caspase-3 (Casp3), Poly [ADP-ribose] polymerase-1 (PARP-1), 8-OHdG immunoreactivities, and apoptotic cells markedly raised in the CBZ group compared with the control group. Also, mRNA expression of Cytochrome c (Cytc) and CASP3 significantly increased in the CBZ group compared to the control group. In conclusion, long-term use of CBZ may promote renal damage in rats by inducing oxidative stress and apoptosis.
Açıklama
Anahtar Kelimeler
Carbamazepine; oxidative stress; renal toxicity; apoptosis; 8-hydroxy-2- deoxyguanosine; poly [ADPribose] polymerase-1
Kaynak
Drug and Chemical Toxicology
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
Sayı
Künye
Erdem Guzel, E., Kaya Tektemur, N., Tektemur, A. & Etem Önalan, E. (2021). Carbamazepine-induced renal toxicity may be associated with oxidative stress and apoptosis in male rat, Drug and Chemical Toxicology, DOI:10.1080/01480545.2021.2014859
https://doi.org/10.1080/01480545.2021.2014859
Bağlantı
https://doi.org/10.1080/01480545.2021.2014859
https://www.scopus.com/record/display.uri?eid=2-s2.0-85121339275&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=4cc50a45a04fe5dd3dc7da66152b226f&featureToggles=FEATURE_NEW_DOC_DETAILS_EXPORT:1
https://hdl.handle.net/20.500.12514/3056
https://www.webofscience.com/wos/woscc/full-record/WOS:000728422400001?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=E1579H1bfcewtgOvZ82
https://pubmed.ncbi.nlm.nih.gov/34879783/
https://www.scopus.com/record/display.uri?eid=2-s2.0-85121339275&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=4cc50a45a04fe5dd3dc7da66152b226f&featureToggles=FEATURE_NEW_DOC_DETAILS_EXPORT:1
https://hdl.handle.net/20.500.12514/3056
https://www.webofscience.com/wos/woscc/full-record/WOS:000728422400001?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=E1579H1bfcewtgOvZ82
https://pubmed.ncbi.nlm.nih.gov/34879783/
