King Oyster Mushroom, Pleurotus eryngii (Agaricomycetes), Extract Can Attenuate Doxorubicin-Induced Lung Damage by Inhibiting Oxidative Stress in Rats

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dc.contributor.authorKaya Tektemur, Nalan
dc.contributor.authorTektemur, Ahmet
dc.contributor.authorGüzel, Elif Erdem
dc.date.accessioned2023-01-17T12:28:11Z
dc.date.available2023-01-17T12:28:11Z
dc.date.issued2023en_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Ebelik Bölümüen_US
dc.description.abstractDoxorubicin (DOX), a broad spectrum chemotherapeutic, has toxic effects on healthy tissues. Mitochondrial processes and oxidative stress act in the DOX-induced toxicity, therefore antioxidant therapies are widely used. The study was aimed to evaluate the therapeutic potential of Pleurotus eryngii extract (PEE), an extract of a fungus with antioxidant properties, against DOX-induced lung damage. Rats were divided into Control, DOX, DOX + PEE, and PEE groups (n = 6). DOX was administered intraperitoneally in a single dose (10 mg/kg BW) and PE (200 mg/kg BW) was administered by oral gavage every other day for 21 days. Histopathological evaluations, immunohistochemical analyses, total oxidant status (TOS)/total antioxidant status (TAS) method, and quantitative real-time polymerase chain reaction (qRT-PCR) analysis were performed. DOX led to severe histopathological disruptions in rat lungs. Also, DOX remarkably increased the expression of dynamin 1 like (DRP1) and decreased the expression of mitofusin 1 (MFN1) and mitofusin 2 (MFN2) genes, which are related to mitochondrial dynamics. Moreover, DOX caused an increase in TOS/ TAS and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels. On the other hand, PEE treatment remarkably normalized the histopathological findings, mitochondrial dynamics-related gene expressions, markers of oxidative stress, and DNA damage. The present study signs out that PEE can ameliorate the DOX-mediated lung toxicity and the antioxidant mechanism associated with mitochondrial dynamics can have a role in this potent therapeutic effect.en_US
dc.identifier.citationTektemur, N. K., TEKTEMUR, A., & Güzel, E. E. King Oyster Mushroom, Pleurotus eryngii (Agaricomycetes) Extract Can Attenuate Doxorubicin-Induced Lung Damage by Inhibiting Oxidative Stress in Rats. International Journal of Medicinal Mushrooms.en_US
dc.identifier.doi10.1615/IntJMedMushrooms.2022046311en_US
dc.identifier.endpage12en_US
dc.identifier.issue1en_US
dc.identifier.pmid36734915en_US
dc.identifier.scopus2-s2.0-85143700220en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85143700220&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=23b76e23725fdfce7db306339fa9b31e
dc.identifier.urihttps://hdl.handle.net/20.500.12514/3335
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/36734915/
dc.identifier.volume25en_US
dc.identifier.wosWOS:000905673100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInternational Journal of Medicinal Mushroomsen_US
dc.relation.ispartofInternational Journal of Medicinal Mushroomsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdrug toxicity, Pleurotus eryngii extract, lung, mitochondria, oxidative damage, medicinal mushroomsen_US
dc.titleKing Oyster Mushroom, Pleurotus eryngii (Agaricomycetes), Extract Can Attenuate Doxorubicin-Induced Lung Damage by Inhibiting Oxidative Stress in Ratsen_US
dc.typeArticleen_US

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