Can Serum Biomarker Values from Second-Trimester Aneuploidy Screening Predict the development of Retinopathy of Prematurity in Premature Infants?

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dc.contributor.authorSabancı, Şenol
dc.contributor.authorKüçük, Mehmet Fatih
dc.contributor.authorSavaş, Hasan Basri
dc.contributor.authorSüren, Elçin
dc.contributor.authorErol, Muhammet Kazım
dc.contributor.authorYavuz, And
dc.contributor.authorSipahioğlu, Haydar
dc.date.accessioned2024-06-12T08:48:15Z
dc.date.available2024-06-12T08:48:15Z
dc.date.issued2024
dc.departmentMAÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjectives: This study aimed to evaluate serum biomarker values measured during second-trimester aneuploidy screening in terms of their predictive ability for the development of retinopathy of prematurity (ROP) in premature infants. Methods: This retrospective cohort study evaluated the data of 1985 idiopathic premature infants who underwent ROP screening from 2016 to 2022. The infants were divided into two groups according to the presence of ROP, and those with ROP were further evaluated in two subgroups based on the presence of proliferation. Comparisons were made concerning the serum multiple of the median values of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and alpha-fetoprotein (AFP) among aneuploidy screening biomarkers. Results: While 1628 premature infants were in the non-ROP group, 357 were in the ROP group. Of the infants with ROP, 72 were in the proliferative ROP group and 285 in the non-proliferative ROP group. There was no significant difference in the multiple of the median values of the evaluated serum biomarkers (uE3, hCG, and AFP) between the ROP and non-ROP groups or between the proliferative ROP, non-proliferative ROP, and non-ROP groups. Conclusion: The multiple of the median values of second-trimester aneuploidy screening serum biomarkers were not able to predict the development of ROP in premature infants. This result may have been caused by the fact that the blood tests were taken only once and in the same weeks.
dc.identifier.citationSabanci S, Kucuk MF, Savas HB, Suren E, Erol MK, Yavuz A, et al. Can Serum Biomarker Values from Second-Trimester Aneu ploidy Screening Predict the development of Retinopathy of Prematurity in Premature Infants? Beyoglu Eye J 2024; 9(2): 95-100.
dc.identifier.doi10.14744/bej.2024.81598
dc.identifier.endpage100
dc.identifier.issue2
dc.identifier.pmid38854900
dc.identifier.scopusqualityQ4
dc.identifier.startpage95
dc.identifier.urihttps://doi.org/10.14744/bej.2024.81598
dc.identifier.urihttps://hdl.handle.net/20.500.12514/5886
dc.identifier.volume9
dc.identifier.wosqualityN/A
dc.institutionauthorSavaş, Hasan Basri
dc.institutionauthorid0000-0001-8759-4507
dc.language.isoen
dc.publisherKare Publishing
dc.relation.ispartofBeyoglu Eye Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlpha-fetoprotein
dc.subjecthuman chorionic gonadotropin
dc.subjectpremature retinopathy
dc.subjectunconjugated estriol
dc.titleCan Serum Biomarker Values from Second-Trimester Aneuploidy Screening Predict the development of Retinopathy of Prematurity in Premature Infants?
dc.typeArticle

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