Hesperetin may alleviate the development of doxorubicin-induced pulmonary toxicity by decreasing oxidative stress and apoptosis in male rats

Küçük Resim

Dosyalar

1-s2.0-S004081662100183X-main.pdf (8.41 MB)

Tarih

2021

Yazarlar

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Elsevier

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Doxorubicin (DOX) is one of the most widely used chemotherapeutic agents. However, it causes pulmonary toxicity which decreases its clinical use in human cancer therapy. The present study was undertaken to obtain an insight into the potential protective effect of hesperetin (HES) against doxorubicin-induced pulmonary toxicity in rats. The animals were divided into 4 groups with 7 rats per group. The experimental treatments were as follows: Control, DOX, DOX + HES, and HES groups. DOX was administered at the dosage of 15 mg/kg i.p for a single dose. HES was administered at the dosage of 50 mg/kg by oral gavage every other day. After 28 days, biochemical parameters, oxidative stress status, histopathological changes, apoptosis-related genes and apoptotic index (AI) were examined of lung tissue. Histopathological changes, Poly [ADP-ribose] polymerase 1 (PARP-1), Caspase-3 (Casp3), Cytochrome c (Cytc), apoptosis-related genes, and AI significantly increased in the DOX group relative to the control group. Malondialdehyde (MDA) significantly increased, while superoxide dismutase (SOD) and glutathione peroxidase (GPx) decreased in the DOX group relative to the control group. However, histopathological findings, MDA, AI, and PAPR1, Casp3 protein expression, mRNA expression of Cytc significantly decreased, while SOD, GPx increased in the DOX + HES group relative to the DOX group. These results attested HES might be a potential agent for the treatment of DOX-induced pulmonary toxicity.

Açıklama

Anahtar Kelimeler

Apoptosis; Doxorubicin; Hesperetin; Oxidative stress; Poly [ADP-ribose] polymerase 1; Pulmonary toxicity.

Kaynak

Tissue and Cell

WoS Q Değeri

Q2

Scopus Q Değeri

N/A

Cilt

73

Sayı

Künye

Erdem Guzel, E., & Kaya Tektemur, N. (2021). Hesperetin may alleviate the development of doxorubicin-induced pulmonary toxicity by decreasing oxidative stress and apoptosis in male rats. In Tissue and Cell (Vol. 73, p. 101667). Elsevier BV. https://doi.org/10.1016/j.tice.2021.101667

Bağlantı

https://doi.org/10.1016/j.tice.2021.101667
 https://pubmed.ncbi.nlm.nih.gov/34653889/#affiliation-1
 https://hdl.handle.net/20.500.12514/2890
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85116937423&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=e591d92435b6818862c80b1529a849ce
 https://www.webofscience.com/wos/woscc/full-record/WOS:000744263100001?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=E1579H1bfcewtgOvZ82

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