Anti-angiogenic and oxidative effects of sodium benzoate at different concentrations in chorioallantoic membrane model.

Küçük Resim Yok

Tarih

2023

Yazarlar

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Modestum

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Aim: Due to the increased consumption of packaged foods, exposure to food additives is also increasing. Sodium benzoate (SB), a frequently used food additive, is generally used in alcoholic beverages, fruit, and vegetable juices, carbonated soft drinks, canned food, and various sauces. It is used to inhibit the formation of mold, yeast, and bacteria. This study was carried out to investigate the effects of SB exposure on angiogenesis and oxidant-antioxidant balance. Materials & methods: Three different concentrations of SB, bevacizumab, and empty pellets were prepared, placed on chorioallantoic membrane (CAM), and examined for antiangiogenesis. Total antioxidant capacity (TAC) and total oxidant capacity (TOC) measurements were made in the albumen samples, and oxidative stress index (OSI) value was calculated. Results: The control group had no anti-angiogenic effect, but the bevacizumab group had a strong anti-angiogenic effect.10-3 M SB had a weak anti-angiogenic effect, but 10-4 M SB and 10-5 M SB showed no anti-angiogenic effect. TOC levels increased with SB in a dose-dependent manner. TAC levels decreased depending on the dose in the experimental groups with SB application. OSI levels increased depending on the dose increase in SB. Conclusions: SB exposure caused a dose-dependent increase in oxidative stress and antiangiogenic effect in CAM model.

Açıklama

Anahtar Kelimeler

Keywords: sodium benzoate, chorioallantoic membrane, food ingredient, oxidant, antioxidant, angiogenesis

Kaynak

J CLIN EXP INVEST.

WoS Q Değeri

Scopus Q Değeri

Cilt

14

Sayı

4

Künye

Dinc E, Sozen ME, Savas HB. Anti-angiogenic and oxidative effects of sodium benzoate at different concentrations in chorioallantoic membrane model. J CLIN EXP INVEST. 2023;14(4):em00831. https://doi.org/10.29333/jcei/13893.