Anti-angiogenic and oxidative effects of sodium benzoate at different concentrations in chorioallantoic membrane model.

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dc.authoridhttps://orcid.org/0000-0001-8759-4507en_US
dc.date.accessioned2023-12-22T12:55:58Z
dc.date.available2023-12-22T12:55:58Z
dc.date.issued2023en_US
dc.departmentMAÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractAim: Due to the increased consumption of packaged foods, exposure to food additives is also increasing. Sodium benzoate (SB), a frequently used food additive, is generally used in alcoholic beverages, fruit, and vegetable juices, carbonated soft drinks, canned food, and various sauces. It is used to inhibit the formation of mold, yeast, and bacteria. This study was carried out to investigate the effects of SB exposure on angiogenesis and oxidant-antioxidant balance. Materials & methods: Three different concentrations of SB, bevacizumab, and empty pellets were prepared, placed on chorioallantoic membrane (CAM), and examined for antiangiogenesis. Total antioxidant capacity (TAC) and total oxidant capacity (TOC) measurements were made in the albumen samples, and oxidative stress index (OSI) value was calculated. Results: The control group had no anti-angiogenic effect, but the bevacizumab group had a strong anti-angiogenic effect.10-3 M SB had a weak anti-angiogenic effect, but 10-4 M SB and 10-5 M SB showed no anti-angiogenic effect. TOC levels increased with SB in a dose-dependent manner. TAC levels decreased depending on the dose in the experimental groups with SB application. OSI levels increased depending on the dose increase in SB. Conclusions: SB exposure caused a dose-dependent increase in oxidative stress and antiangiogenic effect in CAM model.en_US
dc.identifier.citationDinc E, Sozen ME, Savas HB. Anti-angiogenic and oxidative effects of sodium benzoate at different concentrations in chorioallantoic membrane model. J CLIN EXP INVEST. 2023;14(4):em00831. https://doi.org/10.29333/jcei/13893.en_US
dc.identifier.doi10.29333/jcei/13893en_US
dc.identifier.endpageem00831en_US
dc.identifier.issue4en_US
dc.identifier.startpageem00831en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12514/5159
dc.identifier.volume14en_US
dc.institutionauthorSavaş, Hasan Basri
dc.language.isoenen_US
dc.publisherModestumen_US
dc.relation.ispartofJ CLIN EXP INVEST.en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKeywords: sodium benzoate, chorioallantoic membrane, food ingredient, oxidant, antioxidant, angiogenesisen_US
dc.titleAnti-angiogenic and oxidative effects of sodium benzoate at different concentrations in chorioallantoic membrane model.en_US
dc.typeArticleen_US

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