Determination of Antioxidant and cytotoxic activities of king oyster mushroom mediated AgNPs synthesized with environmentally friendly methods

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dc.authorid0000-0002-7732-106Xen_US
dc.authorid0000-0001-8133-6670en_US
dc.contributor.authorAcay, Hilal
dc.contributor.authorBaran, Mehmet Fırat
dc.date.accessioned2021-06-21T10:26:54Z
dc.date.available2021-06-21T10:26:54Z
dc.date.issued2020en_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractSynthesizing nanoparticles (NPs) using wild edible fungi with environmentally friendly synthesis methods is more preferred because of the advantages it provides. The fact that its synthesis is easy, economical, non-toxic and has a wide range of uses increases the interest in this subject. The aim of this study was to determine the antioxidant and cytotoxic activity of biomolecular synthesized Pleurotus eryngii silver nanoparticles (PE-AgNPs) against human prostate carcinoma (PC-3), human cervix (HeLa) and breast carcinoma (MCF-7) cells. PE-AgNPs showed significant cytotoxic activity against HeLa, PC-3, MCF-7 cell lines, and also dimethyl sulfoxide solvents of PE-AgNPs applied for their metal chelating activity, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity and antioxidant activity using the β-carotene linoleate model system. Biosynthetic PE-AgNPs were found to inhibit the proliferation of PC-3, HeLa and MCF-7 cells with IC50 values of 2.185, 46.594 and 6.169 µg / ml, respectively, during a 24-hour incubation period. With the parallel of increasing concentration (1, 2, 5, 10 mg/mL) the activities were also increased at all the tests studied. At 10 mg/ml antioxidant activities were 82%, 85% and 77% for chelation of ferrous ions reducing power, DPPH scavenging and β-carotene linoleate tests respectively. The results show that PE-AgNPs may contribute to the development of a suitable anticancer drug that can lead to a new development of nanoparticles for cancer treatment. It also appears to be advantageous to use nanotechnology and green chemistry to improve the existing therapeutic properties of P.eryngii.en_US
dc.identifier.citationACAY H,BARAN M. F (2020). Determination of Antioxidant and cytotoxic activities of king oyster mushroom mediated AgNPs synthesized with environmentally friendly methods. Medicine Science, 9(3), 760 - 765. Doi: 10.5455/medscience.2020.02.014en_US
dc.identifier.doi10.5455/medscience.2020.02.014en_US
dc.identifier.endpage765en_US
dc.identifier.issn2147-0634
dc.identifier.issn2147-0634
dc.identifier.issue3en_US
dc.identifier.startpage760en_US
dc.identifier.trdizinid367590en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpZM05Ua3dNQT09/determination-of-antioxidant-and-cytotoxic-activities-of-king-oyster-mushroom-mediated-agnps-synthesized-with-environmentally-friendly-methods
dc.identifier.urihttps://doi.org/10.5455/medscience.2020.02.014
dc.identifier.urihttps://hdl.handle.net/20.500.12514/2570
dc.identifier.volume9en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMedicine Scienceen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMetal nanoparticle, Pleurotus eryngii, HeLa, PC3, MCF-7, Antioxidant.en_US
dc.titleDetermination of Antioxidant and cytotoxic activities of king oyster mushroom mediated AgNPs synthesized with environmentally friendly methodsen_US
dc.typeArticleen_US

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