The investigation of effect of alpha lipoic acid against damage on neonatal rat lung to maternal tobacco smoke exposure

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dc.contributor.authorErdem Güzel, Elif
dc.contributor.authorKaya, Nalan
dc.contributor.authorOzan, Gonca
dc.contributor.authorTektemur, Ahmet
dc.contributor.authorDabak, Durrin Özlem
dc.contributor.authorOzan, İbrahim Enver
dc.date.accessioned14.07.201910:50:10
dc.date.accessioned2019-07-16T20:43:54Z
dc.date.available14.07.201910:50:10
dc.date.available2019-07-16T20:43:54Z
dc.date.issued2018
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Ebelik Bölümüen_US
dc.description.abstractThis study was carried out to determine the changes in the lungs of the rat pups exposed to tobacco smoke during pregnancy period and to investigate the protective effects of alpha lipoic acid, which is administered during pregnancy, on these changes. Spraque-Dawley female rats were divided into four groups: control, tobacco smoke (TS), tobacco smoke + alpha lipoic acid (TS + ALA) and alpha lipoic acid (ALA). The rats in control group were untreated. Rats were exposed to TS twice a day for one hour starting from eight weeks before mating and during pregnancy. 20 mg / kg of ALA was administered to rats. On 7th and 21st days 7 of the pups from each group were decapitated. Histological, morphometric, biochemical and quantitative real-time RT-PCR analyzes were performed. Histopathological and biochemical changes were observed in TS group. While a significant decrease was observed both in SP-A and VEGF immunoreactivities and mRNA levels, caspase-3 immunoreactivity and TUNEL positive cells were increased in TS group. It is suggested that prenatal TS exposure leads to morphological and histopathological changes on lung development by causing oxidative damage in lungs of neonatal rats and the maternal use of ALA can provide a limited protective effect on the neonatal lung development against this oxidative stress originating from TS. Although pregnant women are increasingly aware on health risks of smoking, environmental tobacco smoke exposure is still a widespread problem. For this reason, it is thought that this damage can be partially reduced by some antioxidant supplements in pregnancy.en_US
dc.description.sponsorshipFirat University Scientific Research Projects Unit, Elazig, TURKEY [16.06]en_US
dc.description.sponsorshipThe study was supported by the Firat University Scientific Research Projects Unit, Elazig, TURKEY, Project number 16.06.en_US
dc.identifier.doi10.1016/j.toxrep.2018.05.014en_US
dc.identifier.endpage722en_US
dc.identifier.issn2214-7500
dc.identifier.pmid29984187en_US
dc.identifier.scopus2-s2.0-85048255442en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage714en_US
dc.identifier.urihttps://doi.org/10.1016/j.toxrep.2018.05.014
dc.identifier.urihttps://hdl.handle.net/20.500.12514/1273
dc.identifier.volume5en_US
dc.identifier.wosWOS:000452653400091en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofTOXICOLOGY REPORTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlpha lipoic aciden_US
dc.subjectLungen_US
dc.subjectNeonateen_US
dc.subjectTobacco smokeen_US
dc.subjectPregnancyen_US
dc.titleThe investigation of effect of alpha lipoic acid against damage on neonatal rat lung to maternal tobacco smoke exposureen_US
dc.typeArticleen_US

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