Investigation of the Effects of Octreotide Agent on Oxidative Stress, 8-Hydroxy Deoxyguanosine in Experimental Hepatic Carcinogenesis Rat Model

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dc.contributor.authorUnsal, Velid
dc.contributor.authorKurutaş, Ergül Belge
dc.date.accessioned2021-11-10T14:22:47Z
dc.date.available2021-11-10T14:22:47Z
dc.date.issued2020en_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractINTRODUCTION: 2-AAF and DEN are well-known liver toxicants commonly used to stimulate tumors in laboratory animals. AIM: The aim of this study was to investigate the effect of octreotide on DEN-induced and 2-AAF-supplemented hepatocarcinogenesis in Wistar albino rats. MATERIALS AND METHODS: In this study, 64 Wistar albino rats were divided into 8 groups. DEN (175 mg/kg) initiated and 2-AAF (20 mg/kg) promoted liver carcinogenesis in rats. The tumor growth inhibitor octreotide (300 μg/kg) was used. Rats were sacrificed at the end of experiment and their liver tissues were taken for the study. SOD, GSH-Px, CAT activities, NO and MDA levels were measured spectrophotometrically. Also, Hsp70 and 8-OHdG was measured by the ELISA method. RESULTS: In group 7, MDA, 8-OHdG, and Hsp70 levels were significantly increased. In addition, SOD, GSH-Px activity was significantly reduced in this group. MDA, 8-OHdG and Hsp70 levels were significantly reduced in Group 8, which received octreotide for treatment. CONCLUSION: DEN and 2-AAF cause very serious liver damage. Octreotide protects the liver from carcinogenesis, increases the activity of cellular antioxidant enzymes and helps reduce DNA damage. Therefore, octreotide may be an inhibitor in tumor cells and may reduce oxidative stress. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.identifier.doi10.3897/folmed.62.e47735en_US
dc.identifier.endpage75en_US
dc.identifier.issue1en_US
dc.identifier.pmid32337899en_US
dc.identifier.scopus2-s2.0-85084169422en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage70en_US
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85084169422&doi=10.3897%2ffolmed.62.e47735&origin=inward&txGid=10aa47766d68245eb0f1a54553f70511&featureToggles=FEATURE_VIEW_PDF:1
dc.identifier.urihttps://hdl.handle.net/20.500.12514/2941
dc.identifier.volume62en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFolia medicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2-AAF, DEN, Hsp70, octreotide, oxidative stressen_US
dc.titleInvestigation of the Effects of Octreotide Agent on Oxidative Stress, 8-Hydroxy Deoxyguanosine in Experimental Hepatic Carcinogenesis Rat Modelen_US
dc.typeArticleen_US

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