Synthesis and biological evaluation of new aza-acyclic nucleosides and their hydrogen complexes from indole
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SpringerLink
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Three novel aza-acyclic nucleosides and two hydrogen complexes were isolated by flash chromatography after being produced in a reaction between indole and dibenzosulfonyl diethylamine (which had previously been prepared) in the presence of sodium and absolute ethanol as a basic catalyst. Structures of new compounds and complexes were determined by 1D-NMR: 1H NMR, 13C NMR, DEPT-135, 2D-NMR: COSY, HMQC, HSQC, HMBC, IR, and MS spectroscopy. The synthesized compounds were evaluated against a wide range of microorganisms, including Gram-positive and Gram-negative bacteria as well as fungal strains. These compounds showed good biological activity.
Açıklama
Anahtar Kelimeler
Nitrogen-based · Indole · Aza-acyclic nucleosides · Acyclovir analogues
Kaynak
Research on Chemical Intermediates
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
48
Sayı
8
Künye
Alhilal, S., Alhilal, M., Gomha, S. M., & Ouf, S. A. (2022). Synthesis and biological evaluation of new aza-acyclic nucleosides and their hydrogen complexes from indole. Research on Chemical Intermediates, 48(8), 3567-3587.
Bağlantı
https://www.webofscience.com/wos/woscc/full-record/WOS:000819274600001?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=EUW1ED0AA4wPbESzeKvWLTjqIZtmj
https://www.scopus.com/record/display.uri?eid=2-s2.0-85133290985&origin=resultslist&sort=plf-f&src=s&st1=10.1007%2fs11164-022-04760-3&sid=fdd1d64269c1f2a06aef897666292db7&sot=b&sdt=b&sl=31&s=DOI%2810.1007%2fs11164-022-04760-3%29&relpos=0&citeCnt=0&searchTerm=
https://hdl.handle.net/20.500.12514/3149
https://www.scopus.com/record/display.uri?eid=2-s2.0-85133290985&origin=resultslist&sort=plf-f&src=s&st1=10.1007%2fs11164-022-04760-3&sid=fdd1d64269c1f2a06aef897666292db7&sot=b&sdt=b&sl=31&s=DOI%2810.1007%2fs11164-022-04760-3%29&relpos=0&citeCnt=0&searchTerm=
https://hdl.handle.net/20.500.12514/3149
