Renoprotective effect of diacerein in rats with partial unilateral ureteral obstruction model

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dc.contributor.authorKölükçü, Engin
dc.contributor.authorUnsal, Velid
dc.contributor.authorFırat, Fatih
dc.contributor.authorGevrek, Fikret
dc.contributor.authorKatar, Muzaffer
dc.date.accessioned2024-04-22T11:31:48Z
dc.date.available2024-04-22T11:31:48Z
dc.date.issued2024
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractObjectives: We aimed to analyze the effects of diacerein in a rat model of partial unilateral ureteral obstruction (PUUO). Methods: We randomly divided 24 female rats into three groups. Control group, PUUO group and PUUO + diacerein group. The PUUO group was subjected to the PUUO model for seven days. The PUUO + diacerein group received oral diacerein (80 mg/kg) for seven days. Spectrophotometric methods were employed to measure oxidative stress parameters, including malondialdehyde (MDA), protein carbonyl (PC) and antioxidant enzyme levels, including glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD), while indicators of renal function, such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinous-associated lipocalin (NGAL), along with inflammatory parameters interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), were assessed using the ELISA method. Inflammatory parameters were measured in blood samples, and other parameters were analyzed in kidney tissue. Hematoxylin-eosin method examinations were used for histological analyses. Results: IL-1beta, TNF-alpha, and IL-6 levels were found to be significantly decreased in the PUUO + diacerein group compared to the PUUO group (p=0.006, p=0.002 and p=0.001, respectively). In the PUUO + diacerein group, GSH-Px and SOD activities increased compared with the PUUO group (p=0.031 and p=0.037, respectively). We also observed a significant improvement in renal function parameters, such as KIM-1 and NGAL levels in the PUUO + diacerein group compared to PUUO (p=0.002 and p=0.012, respectively). The PC and MDA levels were highest in the PUUO group (p<0.001). Similarly, the histopathologic tissue damage was the most prominent PUUO group (p<0.001). Conclusions: Our study found that diacerein is a highly effective pharmacologic agent in alleviating oxidative damage in PUUO model rats.
dc.identifier.citationKölükçü, E., Unsal, V., Fırat, F., Gevrek, F. & Katar, M. (2024). Renoprotective effect of diacerein in rats with partial unilateral ureteral obstruction model. Turkish Journal of Biochemistry. https://doi.org/10.1515/tjb-2023-0237
dc.identifier.doi10.1515/tjb-2023-0237
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1515/tjb-2023-0237
dc.identifier.urihttps://hdl.handle.net/20.500.12514/5863
dc.identifier.wosWOS:001198849800001
dc.identifier.wosqualityQ4
dc.institutionauthorUnsal, Velid
dc.institutionauthorid0000-0003-1415-0563
dc.language.isoen
dc.publisherWALTER DE GRUYTER
dc.relation.ispartofTURKISH JOURNAL OF BIOCHEMISTRY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiacerein
dc.subjectPartial ureteral obstruction
dc.subjectOxidative damage
dc.titleRenoprotective effect of diacerein in rats with partial unilateral ureteral obstruction model
dc.typeArticle

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