Protective Effects of Syringic Acid on Ischemia-Reperfusion Injury in Testicular Torsion: An Experimental Study in a Rat Model

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dc.authorid0000-0003-1415-0563en_US
dc.contributor.authorSarıkaya, Kubilay
dc.contributor.authorKölükçü, Engin
dc.contributor.authorUnsal, Velid
dc.date.accessioned2024-03-06T12:20:40Z
dc.date.available2024-03-06T12:20:40Z
dc.date.issued2023en_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractAim: The purpose of this study was to assess the effectiveness of syringic acid in preventing ischemia-reperfusion injury following detorsion in a rat model of induced testicular torsion.Material and methods: In our study, a total of 24 rats, eight in each group, were used. Group 1 served as the control group. Group 2 underwent testicular torsion and detorsion. Group 3 underwent the same procedures as Group 2, but also received 100 mg/kg syringic acid immediately following ischemia. Spectrophotometric analysis was performed on blood samples, and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), as well as the values of malondialdehyde (MDA), were evaluated under direct microscopic examination of the testis to determine tissue injury. The architecture of the seminiferous tubules and spermatogenesis processes were graded using the Johnsen and Cosentino scoring systems.Results: The mean value of MDA was higher in Group 2 compared to the other groups (p < 0.001). Group 3 demonstrated a decline in the concentrations of proinflammatory cytokines, such as tumor necrosis factor -alpha, interleukin-6, and interleukin-1 beta, as indicated by biochemical analysis of blood samples, when compared to Group 2 (p-values: 0.045, 0.001, and <0.001, respectively). In addition, the improvement in Johnsen and Cosentino scores was significantly higher in Group 3 compared to Group 2 (p = 0.028 and p = 0.001, respectively).Conclusion: These findings suggest that syringic acid has a protective effect against testicular oxidative damage.en_US
dc.identifier.citationSarikaya K, Kölükçü E, Unsal V, et al. (July 24, 2023) Protective Effects of Syringic Acid on Ischemia-Reperfusion Injury in Testicular Torsion: An Experimental Study in a Rat Model. Cureus 15(7): e42390. DOI 10.7759/cureus.42390en_US
dc.identifier.doi10.7759/cureus.42390en_US
dc.identifier.issue7en_US
dc.identifier.pmid37492038en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.42390
dc.identifier.urihttps://hdl.handle.net/20.500.12514/5833
dc.identifier.volume15en_US
dc.identifier.wosWOS:001124244300014en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUnsal, Velid
dc.language.isoenen_US
dc.publisherCUREUS INCen_US
dc.relation.ispartofCUREUS JOURNAL OF MEDICAL SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidative damageen_US
dc.subjectWistar raten_US
dc.subjectOxidanten_US
dc.subjectReperfusion injuryen_US
dc.subjectTesticular torsionen_US
dc.titleProtective Effects of Syringic Acid on Ischemia-Reperfusion Injury in Testicular Torsion: An Experimental Study in a Rat Modelen_US
dc.typeArticleen_US

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