Synthesis and characterization of the branched magnetic polymer for drug delivery systems
Küçük Resim Yok
Tarih
2016
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Erişim Hakkı
info:eu-repo/semantics/restrictedAccess
Özet
Magnetic nanoparticles (MNP) have gained a lot of attention in
biomedical and industrial applications due to their biocompatibil ity, easy of surface modification and magnetic properties. Mag netic nanoparticles can be utilized in versatile ways, very similar
to those of nanoparticles in general. However, the magnetic prop erties of these particles add a new dimension where they can be
manipulated upon application of an external magnetic field. This
property opens up new applications where drugs that are
attached to a magnetic particle to be targeted in the body using a
magnetic field. Often, targeting is achieved by attaching a mole cule that recognizes another molecule that is specific to the
desired target area.
In recent years, the development of the systems in which drug
is delivered magnetically to the target is drawing considerable
attention since it is a current issue. It is possible to eliminate the
most of the problems caused by high doses of chemotherapy by
using the magnetic drug delivery systems. Therefore, it is impor tant to design delivery systems with high drug loading capacity.
It is necessary to increase the number of reactive groups on the
surface of nanoparticles in order to increase drug loading capac ity.
In this study, we synthesized a novel magnetic surface for drug
delivery systems. Magnetic dextran-NTA (MD-NTA) was synthe sized by using magnetic O-carboxymethyl dextran (OCMD) and
NaNa-Bis (carboxymethyl) -L-lysine hydrate (NTA) in order to
increase the number of reactive carboxyl groups on the surface of
biocompatible and biodegradable magnetic dextran. Magnetic
material (MD-NTA) which was prepared and characterized by
the analysis of Transmission Electron Microscopy (TEM), scan ning electron microscope (SEM), Vibrating Sample Magnetome ter (VSM), Fourier Transform Infrared Spectroscopy (FTIR) and
X-Ray Photoelectron Spectroscopy (XPS).
