Synthesis and characterization of the branched magnetic polymer for drug delivery systems
| dc.date.accessioned | 2023-12-11T13:39:49Z | |
| dc.date.available | 2023-12-11T13:39:49Z | |
| dc.date.issued | 2016 | en_US |
| dc.department | MAÜ, Meslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü | en_US |
| dc.description.abstract | Magnetic nanoparticles (MNP) have gained a lot of attention in biomedical and industrial applications due to their biocompatibil ity, easy of surface modification and magnetic properties. Mag netic nanoparticles can be utilized in versatile ways, very similar to those of nanoparticles in general. However, the magnetic prop erties of these particles add a new dimension where they can be manipulated upon application of an external magnetic field. This property opens up new applications where drugs that are attached to a magnetic particle to be targeted in the body using a magnetic field. Often, targeting is achieved by attaching a mole cule that recognizes another molecule that is specific to the desired target area. In recent years, the development of the systems in which drug is delivered magnetically to the target is drawing considerable attention since it is a current issue. It is possible to eliminate the most of the problems caused by high doses of chemotherapy by using the magnetic drug delivery systems. Therefore, it is impor tant to design delivery systems with high drug loading capacity. It is necessary to increase the number of reactive groups on the surface of nanoparticles in order to increase drug loading capac ity. In this study, we synthesized a novel magnetic surface for drug delivery systems. Magnetic dextran-NTA (MD-NTA) was synthe sized by using magnetic O-carboxymethyl dextran (OCMD) and NaNa-Bis (carboxymethyl) -L-lysine hydrate (NTA) in order to increase the number of reactive carboxyl groups on the surface of biocompatible and biodegradable magnetic dextran. Magnetic material (MD-NTA) which was prepared and characterized by the analysis of Transmission Electron Microscopy (TEM), scan ning electron microscope (SEM), Vibrating Sample Magnetome ter (VSM), Fourier Transform Infrared Spectroscopy (FTIR) and X-Ray Photoelectron Spectroscopy (XPS). | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12514/4552 | |
| dc.institutionauthor | Tarhan, Tuba | |
| dc.institutionauthor | Tural, Bilsen | |
| dc.institutionauthor | Tural, Servet | |
| dc.language.iso | en | en_US |
| dc.relation.publicationcategory | Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/restrictedAccess | en_US |
| dc.title | Synthesis and characterization of the branched magnetic polymer for drug delivery systems | en_US |
| dc.type | Conference Object | en_US |
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