Association with Leptin Gene c.-2548 G > A Polymorphism, Serum Leptin Levels, and Body Mass Index in Turkish Obese Patients

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dc.contributor.authorSay Şahin, Deniz
dc.contributor.authorTümer, Cemil
dc.contributor.authorDemir, Cemil
dc.contributor.authorÇelik, M. Murat
dc.contributor.authorÇelik, Mustafa
dc.contributor.authorUçar, Edip
dc.contributor.authorGüneşaçar, Ramazan
dc.date.accessioned14.07.201910:50:10
dc.date.accessioned2019-07-16T20:44:09Z
dc.date.available14.07.201910:50:10
dc.date.available2019-07-16T20:44:09Z
dc.date.issued2013
dc.departmentMAÜ, Meslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractLeptin is a protein hormone which plays a critical role in the regulation of both body-weight through reducing food intake and stimulating energy expenditure. Several polymorphisms in leptin gene (LEP), which encodes for leptin, have been described. However, its association with obesity is still controversial. Therefore, in the present study, we aimed to investigate whether LEP c.-2548 G > A polymorphism was associated with serum leptin levels, lipid parameters, and body mass index in Turkish obese patients. Forty-seven obese patients and 48 healthy individuals were included in the study. Blood samples were collected for DNA extraction. LEP c.-2548 G > A polymorphism were detected using polymerase chain reaction-restriction fragment length polymorphism technique. Serum leptin levels and lipid parameters were measured by ELISA and enzyme colorimetric assay techniques, respectively. GA or AA genotypes and A allele carrier frequencies of the c.-2548 G > A polymorphism in the LEP were higher in obese (38.3, 34.0 and 72.3 %) when compared with controls (14.6, 12.5, and 27.1 %; p = 0.011, 0.016, and 0.002, respectively). On the other hand, AA or AG genotypes were also related to increased serum leptin levels (p < 0.001) and body mass index (p < 0.0001). All these consequences showed that LEP -2548 AA or AG genotypes are important predictors for increased levels of leptin and BMI in Turkish obese patients and it may be a useful marker for obesity risk in our population.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Projects Unit, Hatay, Turkey [MKUBAP1002Y0102]en_US
dc.description.sponsorshipThis study was supported by a grant from the Mustafa Kemal University Scientific Research Projects Unit, Hatay, Turkey (Project Nr. MKUBAP1002Y0102).en_US
dc.identifier.citationSahin, D. S., Tumer, C., Demir, C., Celik, M. M., Celik, M., Ucar, E., & Gunesacar, R. (2012). Association with Leptin Gene c.-2548 G>A Polymorphism, Serum Leptin Levels, and Body Mass Index in Turkish Obese Patients. Cell Biochemistry and Biophysics, 65(2), 243–247. https://doi.org/10.1007/s12013-012-9427-1
dc.identifier.doi10.1007/s12013-012-9427-1en_US
dc.identifier.endpage247en_US
dc.identifier.issn1085-9195
dc.identifier.issn1559-0283
dc.identifier.issue2en_US
dc.identifier.pmid23054910en_US
dc.identifier.scopus2-s2.0-84874263229en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage243en_US
dc.identifier.urihttps://doi.org/10.1007/s12013-012-9427-1
dc.identifier.urihttps://hdl.handle.net/20.500.12514/1420
dc.identifier.volume65en_US
dc.identifier.wosWOS:000315161000019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHUMANA PRESS INCen_US
dc.relation.ispartofCELL BIOCHEMISTRY AND BIOPHYSICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeptinen_US
dc.subjectc.-2548 G > Aen_US
dc.subjectPolymorphismen_US
dc.subjectObesityen_US
dc.subjectBody mass indexen_US
dc.titleAssociation with Leptin Gene c.-2548 G > A Polymorphism, Serum Leptin Levels, and Body Mass Index in Turkish Obese Patientsen_US
dc.typeArticleen_US

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