Several biological properties and synthesis of 2-(4-methylthiazol-5-yl) ethoxy substitute zinc phthalocyanine

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dc.authorid0000-0002-7930-1054en_US
dc.authorscopusid25623213000en_US
dc.contributor.authorGüngördü Solgun, Derya
dc.contributor.authorÖzdemir, Sadin
dc.contributor.authorDündar, Abdurrahman
dc.contributor.authorAğırtaş, Mehmet Salih
dc.date.accessioned2023-12-08T08:49:48Z
dc.date.available2023-12-08T08:49:48Z
dc.date.issued2023en_US
dc.departmentMAÜ, Meslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractIn this study, 4-(2-(4-methylthiazol-5-yl) ethoxy) phthalonitrile (3) and zinc phthalocyanine complex (4) were synthesized and characterized. UV–vis and fluorescence spectra, aggregation, and fluorescence parameters of the zinc phthalocyanine compound were investigated. As biological properties, DPPH radical capture, antidiabetic, DNA cutting, antimicrobial, photodynamic antimicrobial, anti-biofilm activities, and microbial cell viability parameters of the compounds were determined. The highest antioxidant activity was found as 62.80% at 100 mg/L concentration with compound 4, and compound 4 also showed the best antidiabetic activity as 65.17% at 400 mg/L concentration. In DNA cutting activity, it was determined that 3 and 4 cut DNA at all concentrations. For compounds 3–4, the minimum inhibitory concentration (MIC) values were found to be 32 and 16 mg/L for Enterococcus hirae and Enterococcus feacalis, respectively. The strongest MIC value of photodynamic antimicrobial activity was achieved as 4 mg/L for E. feacalis with 4. It was observed that both compounds inhibited the microbial viability activity of Escherichia coli by 100% at concentrations of 100 mg/L. Compound 4 inhibited biofilms of Pseudomonas aureginosa and Staphylococcus aureus as 92.48% and 98.56% at 50 mg/L concentration, respectively.en_US
dc.identifier.citationSolğun, D. G., Özdemir, S., Dündar, A., & Ağırtaş, M. S. (2023). Several biological properties and synthesis of 2‐(4‐methylthiazol‐5‐yl) ethoxy substitute zinc phthalocyanine. Applied Organometallic Chemistry, aoc.7324. https://doi.org/10.1002/aoc.7324en_US
dc.identifier.doi10.1002/aoc.7324en_US
dc.identifier.issn0268-2605
dc.identifier.scopus2-s2.0-85177781089en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/aoc.7324
dc.identifier.urihttps://hdl.handle.net/20.500.12514/4464
dc.identifier.wosWOS:001108892800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorDündar, Abdurrahman
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Ltden_US
dc.relation.ispartofApplied Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidanten_US
dc.subjectDNA cleavageen_US
dc.subjectPhthalocyanineen_US
dc.subjectSynthesisen_US
dc.titleSeveral biological properties and synthesis of 2-(4-methylthiazol-5-yl) ethoxy substitute zinc phthalocyanineen_US
dc.typeArticleen_US

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