Isocarpine as A New Peperidine Alkaloid from Adenocarpus Complicatus with Anticandidal Activity

Küçük Resim Yok

Tarih

2022

Yazarlar

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Ingenta Connect

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Background: Adenocarpus complicatus L. is one of Adenocarpus genus, which has about 50 species, from Fabaceae (Papilionaceae) family. This plant is found in the Mediterranean basin as a southern west part of Europe and North Afric forestes. Objective: Isolation of Isocarpine From Adenocarpus Complicatus as Anticandidal Agent. Methods: A new piperidine alkaloid Isocarpine was isolated from the aerial parts of Adenocarpus complicatus L., which is gross in Syria. The structure of the new compound was determined by UV, IR, EI-Ms, 1H-NMR, 13C-NMR, DEPT-135, DQF-COSY and HMQC. Results: The anticandidal activity of isocarpine was screened against 38 Candida strains and showed remarkable inhibitory effect compared with fluconazole as an antifungal reference drug. Conclusion: Isocarpine is antifungal agent.

Açıklama

Anahtar Kelimeler

Adenocarpus complicatus L; antifungal activity; fluconazole; isocarpines; piperidine alkaloids; structure elucidation

Kaynak

Natural Products Journal

WoS Q Değeri

N/A

Scopus Q Değeri

N/A

Cilt

12

Sayı

5

Künye

Alhilal, M., Alhilal, S., Gomha, S., & Ouf, S. (2022). Isocarpine as A New Peperidine Alkaloid from Adenocarpus Complicatus with Anticandidal Activity. The Natural Products Journal, 12(5), 79-92.

Bağlantı

https://doi.org/10.2174/2210315511666211015085803
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85132846566&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=16c67a05cb33810fef99d17dd2fe144a
 https://hdl.handle.net/20.500.12514/3145
 https://www.webofscience.com/wos/woscc/full-record/WOS:000830010900010?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=EUW1ED0C13jEGt7Yxd7bywdJHuz5d

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