Isocarpine as A New Peperidine Alkaloid from Adenocarpus Complicatus with Anticandidal Activity

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dc.authorid0000-0002-2832-8409en_US
dc.contributor.authorAlhilal, Mohammad
dc.contributor.authorAlhilal, Suzan
dc.contributor.authorGomha, Sobhi
dc.date.accessioned2022-10-10T10:41:37Z
dc.date.available2022-10-10T10:41:37Z
dc.date.issued2022en_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümüen_US
dc.description.abstractBackground: Adenocarpus complicatus L. is one of Adenocarpus genus, which has about 50 species, from Fabaceae (Papilionaceae) family. This plant is found in the Mediterranean basin as a southern west part of Europe and North Afric forestes. Objective: Isolation of Isocarpine From Adenocarpus Complicatus as Anticandidal Agent. Methods: A new piperidine alkaloid Isocarpine was isolated from the aerial parts of Adenocarpus complicatus L., which is gross in Syria. The structure of the new compound was determined by UV, IR, EI-Ms, 1H-NMR, 13C-NMR, DEPT-135, DQF-COSY and HMQC. Results: The anticandidal activity of isocarpine was screened against 38 Candida strains and showed remarkable inhibitory effect compared with fluconazole as an antifungal reference drug. Conclusion: Isocarpine is antifungal agent.en_US
dc.identifier.citationAlhilal, M., Alhilal, S., Gomha, S., & Ouf, S. (2022). Isocarpine as A New Peperidine Alkaloid from Adenocarpus Complicatus with Anticandidal Activity. The Natural Products Journal, 12(5), 79-92.en_US
dc.identifier.doi10.2174/2210315511666211015085803en_US
dc.identifier.endpage92en_US
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85132846566en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.2174/2210315511666211015085803
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85132846566&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=16c67a05cb33810fef99d17dd2fe144a
dc.identifier.urihttps://hdl.handle.net/20.500.12514/3145
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000830010900010?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=EUW1ED0C13jEGt7Yxd7bywdJHuz5d
dc.identifier.volume12en_US
dc.identifier.wosWOS:000830010900010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIngenta Connecten_US
dc.relation.ispartofNatural Products Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdenocarpus complicatus L; antifungal activity; fluconazole; isocarpines; piperidine alkaloids; structure elucidationen_US
dc.titleIsocarpine as A New Peperidine Alkaloid from Adenocarpus Complicatus with Anticandidal Activityen_US
dc.typeArticleen_US

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