Synthesis and biological properties of axially bis − (3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV)
Yükleniyor...
Dosyalar
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, bis − (3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV) was obtained from the reaction of 3,4,5-trimethoxybenzyl alcohol with SiPcCl2. This phthalocyanine was characterized using 1H NMR, FTIR, UV–vis and mass spectra. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, antidiabetic, deoxyribonucleic acid (DNA) cutting, biofilm inhibition, anti-microbial and antimicrobial photodynamic therapy (aPDT) activities of newly synthesized bis − (3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV) molecule were studied. The best activities were 41.58 % at 100 mg/L for antioxidant and 41.66 % for antidiabetic at 400 mg/L concentration. The molecule degraded the biofilm matrix formed by Pseudomonas aeruginosa and Staphylococcus aureus as 78.61 % and 89.26 %, at 50 mg/L concentration, respectively. It was observed that E. coli, which was used as a model microorganism, was inhibited at a level close to 100 % even at the lowest concentration of 50 mg/L. While double strand break was observed at 50 mg/L DNA cutting activity, it was determined that DNA was reduced to nucleotides at 100 and 200 mg/L. The Pc also displayed effective antimicrobial and aPDT abilities against pathogens. With the application of aPDT, the effectiveness of antimicrobial activity increased 2 to 4 times. These increase rates are very important. The main conclusion of the study was that the newly synthesized compound exhibited various effective biological activities such as effective antioxidant, antidiabetic, DNA cleavage, antimicrobial, aPDT, biofilm inhibition and microbial cell viability inhibition.
Açıklama
Anahtar Kelimeler
Antimicrobial, Antioxidant, Biofilm inhibition, Fluorescence, Silicon phthalocyanine
Kaynak
Journal of Photochemistry and Photobiology A: Chemistry
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
456
Sayı
Künye
Güngördü Solğun, D., Özdemir, S., Dündar, A., & Salih Ağırtaş, M. (2024). Synthesis and biological properties of axially bis − (3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (iv). Journal of Photochemistry and Photobiology A: Chemistry, 115794. https://doi.org/10.1016/j.jphotochem.2024.115794
