Protective effects of dexmedetomidine on ischaemia-reperfusion injury in an experimental rat model of priapism
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Andrologia
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The study aimed to investigate the effects of dexmedetomidine against ischaemia-reperfusion injury occurring after priapism in a model of induced-priapism in rats. A total of 18 male rats were randomised into three groups. Group 1 was the control group. A priapism model was performed rats in Group 2 and then ischaemia-reperfusion injury was evaluated. Group 3 had similar procedures to the rats in Group 2. Rats in Group 3 additionally had 100 μg/kg dexmedetomidine administered intraperitoneally immediately after reperfusion. Blood and tissue samples were analysed. Biochemical analysis of blood samples revealed a decrease in the levels of the pro-inflammatory cytokines including interleukin-1 beta (IL-1 Beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha) in Group 3 compared to Group 2 (p:.04, p:.009 and p:.009, respectively). Similarly, the highest malondialdehyde (MDA) level was in Group 2 (p:.002). The levels of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were significantly higher in Group 3 than that of Group 2 (p:.037 and p:.045, respectively). Direct microscopic examinations revealed positive changes in desquamation, oedema, inflammation and vasocongestion scores in Group 3 compared to Group 2 (p:.007, p:.008, p:.007 and p:.006, respectively). Dexmedetomidine has a protective effect against ischaemia-reperfusion injury in penile tissue.
Açıklama
Anahtar Kelimeler
dexmedetomidine, ischaemia reperfusion injury, priapism
Kaynak
Andrologia
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
53
Sayı
3
Künye
Kölükçü, E., Parlaktaş, B. S., Kölükçü, V., Firat, F., Deresoy, F. A., Katar, M., Kuyucu, Y. E., & Unsal, V. (2021). Protective effects of dexmedetomidine on ischaemia‐reperfusion injury in an experimental rat model of priapism. In Andrologia (Vol. 53, Issue 3). Wiley. https://doi.org/10.1111/and.13985
Bağlantı
https://www.scopus.com/record/display.uri?eid=2-s2.0-85100024639&doi=10.1111%2fand.13985&origin=inward&txGid=c9d4e0ce10fcab8d19291841b50d6c55&featureToggles=FEATURE_NEW_METRICS_SECTION:1
https://hdl.handle.net/20.500.12514/2683
https://doi.org/10.1111/and.13985
https://pubmed.ncbi.nlm.nih.gov/33474739/
https://hdl.handle.net/20.500.12514/2683
https://doi.org/10.1111/and.13985
https://pubmed.ncbi.nlm.nih.gov/33474739/
