Synthesis and characterization of silver nanoparticles decorated polydopamine coated hexagonal boron nitride and its effect on wound healing

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dc.contributor.authorTarhan, Tuba
dc.contributor.authorŞen, Özlem
dc.contributor.authorEmanet Ciofani, Melis
dc.contributor.authorYılmaz, Deniz
dc.contributor.authorÇulha, Mustafa
dc.date.accessioned2021-07-13T08:44:03Z
dc.date.available2021-07-13T08:44:03Z
dc.date.issued2021en_US
dc.departmentMAÜ, Meslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Sağlık ve Bakım Hizmetleri Bölümüen_US
dc.description.abstractBackground: Wound healing is an essential physiological process involving many cell types and their products acting in a marvellous harmony to repair damaged tissues. During the healing process, cellular proliferation and extracellular matrix remodelling stages could be interrupted by undesired factors including microorganisms and altered metabolic activities. In such a case, the process requires some external stimulants to accelerate or remediate the healing stages. Methods: In this study, we report a multifunctional wound healing stimulating agent. In this context, hexagonal boron nitride (hBN) nanoparticles, silver nanoparticles (AgNPs) and polydopamine(pdopa) were used through mussel-inspired chemistry of dopamine to obtain pdopa coated hBN (hBN@pdopa) and AgNPs decorated hBN@pdopa (hBN@pdopa-AgNPs). These two nanostructures were investigated to observe stages of healing. Results: AgNPs were chosen for inflammation reduction and hBN for induced cell proliferation and migration. In in vitro experiments, firstly, high cellular uptake capacity and biocompatibility of hBN@pdopa and hBN@pdopa-AgNPs were evaluated. They were also tested for their reaction against increased concentration of reactive oxygen species (ROS) in injured cells. Finally, their effect on cellular migration, intracellular tube formation and F-actin organization were monitored by light and confocal microscopy, respectively. Conclusion: The results clearly indicate that the hBN@pdopa-AgNPs significantly decrease ROS production, promote wound closure, and reorganize tube formation in cells.en_US
dc.identifier.citationTarhan, T., Şen, Ö., Ciofani, M. E., Yılmaz, D., & Çulha, M. (2021). Synthesis and characterization of silver nanoparticles decorated polydopamine coated hexagonal boron nitride and its effect on wound healing. In Journal of Trace Elements in Medicine and Biology (Vol. 67, p. 126774). Elsevier BV. https://doi.org/10.1016/j.jtemb.2021.126774
dc.identifier.doi10.1016/j.jtemb.2021.126774en_US
dc.identifier.pmid33984543en_US
dc.identifier.scopus2-s2.0-85105451427en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://hdl.handle.net/20.500.12514/2659
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/33984543/
dc.identifier.volume67en_US
dc.identifier.wosWOS:000663552700006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJournal of Trace Elements in Medicine and Biologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesis; Biocompatibility; Hexagonal boron nitrides; Polydopamine; Silver nanoparticles; Wound healing.en_US
dc.titleSynthesis and characterization of silver nanoparticles decorated polydopamine coated hexagonal boron nitride and its effect on wound healingen_US
dc.typeArticleen_US

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