Investigation of the Protective Activity of Baicalein on the Lungs via Regulation of Various Cellular Responses in Rats Exposed to Experimental Sepsis

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dc.authorid0000-0002-7658-7763en_US
dc.authorscopusid57034160700en_US
dc.authorwosidJPL-2578-2023en_US
dc.contributor.authorDicle, Yalçın
dc.contributor.authorAydın, Elif
dc.contributor.authorŞeker, Uğur
dc.date.accessioned2023-12-12T19:03:32Z
dc.date.available2023-12-12T19:03:32Z
dc.date.issued2023en_US
dc.departmentMAÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractBackgrounds In the present study, a cecal ligation and puncture (CLP)-induced experimental sepsis rat model was used to explore the effects of baicalein on inflammatory cytokine levels and oxidative stress as well as the possible regulatory role of nuclear factor-kappa B (NF-κB). Methods For that purpose, 42 Wistar albino rats were equally divided into control, sham, sepsis, B50 + S, B100 + S, S + B50, and S + B100 groups. The B50 + S and B100 + S groups received baicalein before the induction of sepsis, while the S + B50 and S + B100 groups received baicalein afterwards. Experimental sepsis in related groups is generated through ligation of cecum and a puncture in cecal wall. Serum samples were used for tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) analyses, and tissue Malondialdehyde (MDA), Superoxide dismutase (SOD), Glutathione (GSH), IL-6, and NF-κB levels were measured. Results Compared to the control group, there were significantly increases in the serum TNF-α, IL-6, tissue MDA, and NF-κB levels and decreases in the tissue SOD and GSH levels in the septic group (P < 0.05). Compared to the septic group, inflammation and oxidative stress were reduced in the baicalein-treated groups. Although all of the pre- and post-treatment protocols alleviated inflammation and oxidative stress to varying degrees, pre-treatment with 100 mg/kg was the most successful. Conclusions Findings of this study indicated that baicalein has the potential to reduce sepsis-related oxidative stress and inflammation in the lungs and that pathological outcomes could be regulated via NF-κB transcription factor activity.en_US
dc.identifier.citationYalcin Dicle, Elif Aydin, Ugur Seker, Investigation of the protective activity of baicalein on the lungs via regulation of various cellular responses in rats exposed to experimental sepsis, Toxicology Research, 2023;, tfad112, https://doi.org/10.1093/toxres/tfad112en_US
dc.identifier.doi10.1093/toxres/tfad112en_US
dc.identifier.endpage8en_US
dc.identifier.issue1en_US
dc.identifier.pmid38178997en_US
dc.identifier.scopus2-s2.0-85182368805en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1093/toxres/tfad112
dc.identifier.urihttps://hdl.handle.net/20.500.12514/4606
dc.identifier.volume13en_US
dc.identifier.wosWOS:001114864100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDicle, Yalçın
dc.institutionauthorŞeker, Uğur
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofToxicology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbaicaleinen_US
dc.subjectsepsisen_US
dc.subjectinflammationen_US
dc.subjectoxidativestressen_US
dc.subjectNF-κBen_US
dc.titleInvestigation of the Protective Activity of Baicalein on the Lungs via Regulation of Various Cellular Responses in Rats Exposed to Experimental Sepsisen_US
dc.typeArticleen_US

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