Osajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimation
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Online
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This paper aimed to examine the impact of flavonoid osajin (OSJ) on liver damage induced
by sepsis. A total of 30 male rats were divided into 5 groups (Sham, sepsis, OSJ 150, OSJ 300
and reference). During sepsis, elevated lipid peroxidation (LPO) level and catalase activity (CAT)
and decreased glutathione (GSH) level and superoxide dismutase (SOD) activity were observed
in hepatic tissues of sepsis group in comparison with Sham group. A strong interleukin-33
and caspase-3 expressions were detected in hepatic tissues of sepsis group. On the contrary,
OSJ administration to OSJ 300 group showed a significant decrease (P < 0.001) in LPO level
(176±2.926) and significant increase (P < 0.001) in GSH level (10.586±0.083) and SOD activity
(29.152±0.094) in comparison with sepsis group (185.777±1.735, 8.246±0.124, 24.307±0.379
respectively). In addition, the consumption of OSJ reduced expressions of interleukin-33 and
caspase-3 and improved histopathological integrity. In conclusions, OSJ has hepatoprotective
effect against sepsis-induced liver injury.
Açıklama
Anahtar Kelimeler
Liver; osajin; oxidative stress; sepsis
Kaynak
Journal of Taibah University for Science
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
17
Sayı
1
Künye
Alhilal, M., Erol, H. S., Yildirim, S., Cakir, A., Koc, M., Celebi, D., & Halici, M. B. (2023). Osajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimation. Journal of Taibah University for Science, 17(1), 2201250.
