Osajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimation

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dc.contributor.authorAlhilal, Mohammad
dc.contributor.authorHuseyin Serkan Erol, Serkan Yildirim, Ahmet Cakir, Murat Koc, Demet Celebi, Mesut Bunyami Halici
dc.date.accessioned2023-07-31T11:51:08Z
dc.date.available2023-07-31T11:51:08Z
dc.date.issued2023en_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümüen_US
dc.description.abstractThis paper aimed to examine the impact of flavonoid osajin (OSJ) on liver damage induced by sepsis. A total of 30 male rats were divided into 5 groups (Sham, sepsis, OSJ 150, OSJ 300 and reference). During sepsis, elevated lipid peroxidation (LPO) level and catalase activity (CAT) and decreased glutathione (GSH) level and superoxide dismutase (SOD) activity were observed in hepatic tissues of sepsis group in comparison with Sham group. A strong interleukin-33 and caspase-3 expressions were detected in hepatic tissues of sepsis group. On the contrary, OSJ administration to OSJ 300 group showed a significant decrease (P < 0.001) in LPO level (176±2.926) and significant increase (P < 0.001) in GSH level (10.586±0.083) and SOD activity (29.152±0.094) in comparison with sepsis group (185.777±1.735, 8.246±0.124, 24.307±0.379 respectively). In addition, the consumption of OSJ reduced expressions of interleukin-33 and caspase-3 and improved histopathological integrity. In conclusions, OSJ has hepatoprotective effect against sepsis-induced liver injury.en_US
dc.identifier.citationAlhilal, M., Erol, H. S., Yildirim, S., Cakir, A., Koc, M., Celebi, D., & Halici, M. B. (2023). Osajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimation. Journal of Taibah University for Science, 17(1), 2201250.en_US
dc.identifier.doi10.1080/16583655.2023.2201250en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85153231436en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1080/16583655.2023.2201250
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85153231436&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=865dc01baf7a793bcc78a79120834f5d
dc.identifier.urihttps://hdl.handle.net/20.500.12514/3563
dc.identifier.volume17en_US
dc.identifier.wosWOS:000974619100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Onlineen_US
dc.relation.ispartofJournal of Taibah University for Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiver; osajin; oxidative stress; sepsisen_US
dc.titleOsajin from Maclura pomifera alleviates sepsis-induced liver injury in rats: biochemical, histopathological and immunohistochemical estimationen_US
dc.typeArticleen_US

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