The Effect of N-acetylcysteine on Amylase, Electrolytes, Vitamins and Nitrosative Stress Levels in Rats Treated with Maras Powder

Unsal, Velid; Belge Kurutaş, Ergül

The Effect of N-acetylcysteine on Amylase, Electrolytes, Vitamins and Nitrosative Stress Levels in Rats Treated with Maras Powder

dc.authorid	0000-0003-1415-0563	en_US
dc.authorid	0000-0002-6653-4801	en_US
dc.contributor.author	Unsal, Velid
dc.contributor.author	Belge Kurutaş, Ergül
dc.date.accessioned	2021-06-22T07:47:25Z
dc.date.available	2021-06-22T07:47:25Z
dc.date.issued	2020	en_US
dc.department	MAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü	en_US
dc.description.abstract	The aim of this study is to investigate the effects of N-acetylcysteine (NAC) on amylase, electrolytes, vitamins and nitrosative stress levels in the plasma of rats treated with smokeless tobacco "maras powder". Our study consisted of three groups. Control (n = 10), the group using maras powder (n = 10), maras powder+ NAC group. To the Maras powder group, 200 mg maras powder was placed in the sublingual area under general anesthesia. It was waited for 15 minutes for Maras powder to be absorbed through mucosa. This procedure was repeated once a day and for 7 days. To the NAC group, 200 mg of Maras powder was given as in the Maras powder group and NAC was injected intraperitoneally with a dose of 100 mg / kg / day. On the 8th day, the levels of amylase, vitamins (A, C and E), electrolytes (Na+, K+, Cl- ) and, as the biomarkers of nitrosative stress, nitric oxide (NO) and nitrotyrosine (3-NTx) in the plasma of all three groups were measured by the methods of ELISA. It was determined that amylase, 3-NTx, NO, electrolyte levels increased in the group using Maras powder compared to the control and NAC groups, but vitamin levels decreased. (p <0.05). It was detected that the levels of amylase, 3-NTx, NO, electrolyte in the group treated with NAC decreased compared to the group using Maras powder, whereas vitamin levels significantly increased and approached to the values of the control group. Smokeless tobacco 'Maras powder' increases nitrosative stress and distorts the levels of vitamin A, E, C and electrolyte in the plasma. NAC has a positive function in reducing the damage caused by Maras powder.	en_US
dc.identifier.citation	UNSAL V,KURUTAS E. B (2020). The Effect of N-acetylcysteine on Amylase, Electrolytes, Vitamins and Nitrosative Stress Levels in Rats Treated with Maras Powder. Eastern Journal of Medicine, 25(3), 378 - 382. Doi: 10.5505/ejm.2020.26680	en_US
dc.identifier.doi	10.5505/ejm.2020.26680	en_US
dc.identifier.endpage	382	en_US
dc.identifier.issn	1301-0883
dc.identifier.issn	1339-3886
dc.identifier.issue	3	en_US
dc.identifier.scopus	2-s2.0-85090491955	en_US
dc.identifier.scopusquality	Q4	en_US
dc.identifier.startpage	378	en_US
dc.identifier.trdizinid	377220	en_US
dc.identifier.uri	https://app.trdizin.gov.tr/makale/TXpjM01qSXdNQT09/the-effect-of-n-acetylcysteine-on-amylase-electrolytes-vitamins-and-nitrosative-stress-levels-in-rats-treated-with-maras-powder
dc.identifier.uri	https://doi.org/10.5505/ejm.2020.26680
dc.identifier.uri	https://hdl.handle.net/20.500.12514/2579
dc.identifier.volume	25	en_US
dc.indekslendigikaynak	Scopus	en_US
dc.indekslendigikaynak	TR-Dizin	en_US
dc.language.iso	en	en_US
dc.publisher	Eastern Journal of Medicine	en_US
dc.relation.ispartof	Eastern Journal of Medicine	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı	en_US
dc.rights	info:eu-repo/semantics/openAccess	en_US
dc.subject	Smokeless tobacco, Maras powder, NAC, vitamins, electrolytes	en_US
dc.title	The Effect of N-acetylcysteine on Amylase, Electrolytes, Vitamins and Nitrosative Stress Levels in Rats Treated with Maras Powder	en_US
dc.type	Article	en_US