Evaluation of oxidative stress biomarkers in acute mercury intoxication
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Folia Medica
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: Very few studies have evaluated the association between mercury exposure and oxidative stress in humans, particularly in children.
Aim: This is the first report where we aimed to determine the oxidative stress status of children who were accidentally exposed to elemental mercury.
Materials and methods: In the present study, the study group was composed of 86 randomly selected children poisoned by mercury; the control group was composed of 78 children who had no history of mercury exposure. At admission, blood samples were collected. Blood superoxide dismutase activity, catalase enzyme activity, and glutathione peroxidase activity were measured by Fridovich, Beutler, and Lawrence Burk methods respectively, and the results were given as U/g Hb. Malondialdehyde level was measured by Ohkawa methods, and the results were given as mmol/ml.
Results: Catalase activity was significantly lower in the patient group compared to the control group (1.28±0.62 vs. 3.90±0.86 U/g Hb, p=0.010). In exposed children, SOD activity was significantly higher than the controls (5936±810 vs. 2226±464 U/g Hb, p=0.03), while the GSH-Px activity was significantly lower (13.01±3.21 vs. 34.97±7.32 U/g Hb, p=0.013). The MDA levels of the mercury group were significantly higher than the MDA levels of the control group (2.85±0.84 vs. 2.05±0.79 mmol/ml, p=0.04).
Conclusions: The results of the present study showed that acute mercury poisoning causes an alteration of oxidative stress status in children exposed to elemental mercury.
Açıklama
Anahtar Kelimeler
catalase, glutathione peroxidase, intoxication, malondialdehyde, mercury, superoxide dismutase
Kaynak
Folia Medica
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
63
Sayı
5
Künye
Dalkiran, T., Carman, K. B., Unsal, V., Kurutas, E. B., Kandur, Y., & Dilber, C. (2021). Evaluation of oxidative stress biomarkers in acute mercury intoxication. Folia Medica, 63(5), 704-709.
Bağlantı
https://pubmed.ncbi.nlm.nih.gov/35851205/
https://www.scopus.com/record/display.uri?eid=2-s2.0-85134552333&origin=resultslist&sort=plf-f&src=s&st1=10.3897%2ffolmed.63.e56110&sid=5350159cbae0b12e1be5e92879a56250&sot=b&sdt=b&sl=29&s=DOI%2810.3897%2ffolmed.63.e56110%29&relpos=0&citeCnt=0&searchTerm=
https://hdl.handle.net/20.500.12514/3158
https://www.scopus.com/record/display.uri?eid=2-s2.0-85134552333&origin=resultslist&sort=plf-f&src=s&st1=10.3897%2ffolmed.63.e56110&sid=5350159cbae0b12e1be5e92879a56250&sot=b&sdt=b&sl=29&s=DOI%2810.3897%2ffolmed.63.e56110%29&relpos=0&citeCnt=0&searchTerm=
https://hdl.handle.net/20.500.12514/3158
