Evaluation of oxidative stress biomarkers in acute mercury intoxication

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dc.contributor.authorDalkıran, Tahir
dc.contributor.authorCarman, Kursat Bora
dc.contributor.authorUnsal, Velid
dc.contributor.authorKurutas, Ergul Belge
dc.contributor.authorKandur, Yasar
dc.contributor.authorDilber, Cengiz
dc.date.accessioned2022-11-09T08:46:55Z
dc.date.available2022-11-09T08:46:55Z
dc.date.issued2021en_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractIntroduction: Very few studies have evaluated the association between mercury exposure and oxidative stress in humans, particularly in children. Aim: This is the first report where we aimed to determine the oxidative stress status of children who were accidentally exposed to elemental mercury. Materials and methods: In the present study, the study group was composed of 86 randomly selected children poisoned by mercury; the control group was composed of 78 children who had no history of mercury exposure. At admission, blood samples were collected. Blood superoxide dismutase activity, catalase enzyme activity, and glutathione peroxidase activity were measured by Fridovich, Beutler, and Lawrence Burk methods respectively, and the results were given as U/g Hb. Malondialdehyde level was measured by Ohkawa methods, and the results were given as mmol/ml. Results: Catalase activity was significantly lower in the patient group compared to the control group (1.28±0.62 vs. 3.90±0.86 U/g Hb, p=0.010). In exposed children, SOD activity was significantly higher than the controls (5936±810 vs. 2226±464 U/g Hb, p=0.03), while the GSH-Px activity was significantly lower (13.01±3.21 vs. 34.97±7.32 U/g Hb, p=0.013). The MDA levels of the mercury group were significantly higher than the MDA levels of the control group (2.85±0.84 vs. 2.05±0.79 mmol/ml, p=0.04). Conclusions: The results of the present study showed that acute mercury poisoning causes an alteration of oxidative stress status in children exposed to elemental mercury.en_US
dc.identifier.citationDalkiran, T., Carman, K. B., Unsal, V., Kurutas, E. B., Kandur, Y., & Dilber, C. (2021). Evaluation of oxidative stress biomarkers in acute mercury intoxication. Folia Medica, 63(5), 704-709.en_US
dc.identifier.doi10.3897/folmed.63.e56110en_US
dc.identifier.endpage709en_US
dc.identifier.issue5en_US
dc.identifier.pmid35851205en_US
dc.identifier.scopus2-s2.0-85134552333en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage704en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/35851205/
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85134552333&origin=resultslist&sort=plf-f&src=s&st1=10.3897%2ffolmed.63.e56110&sid=5350159cbae0b12e1be5e92879a56250&sot=b&sdt=b&sl=29&s=DOI%2810.3897%2ffolmed.63.e56110%29&relpos=0&citeCnt=0&searchTerm=
dc.identifier.urihttps://hdl.handle.net/20.500.12514/3158
dc.identifier.volume63en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFolia Medicaen_US
dc.relation.ispartofFolia Medicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcatalase, glutathione peroxidase, intoxication, malondialdehyde, mercury, superoxide dismutaseen_US
dc.titleEvaluation of oxidative stress biomarkers in acute mercury intoxicationen_US
dc.typeArticleen_US

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