Investigation of the relationship cellular and physiological degeneration in the mandible with AQP1 and AQP3 membrane proteins

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dc.contributor.authorUnsal, Velid
dc.contributor.authorÇiçek, Mustafa
dc.contributor.authorTümer, Mehmet Kemal
dc.date.accessioned2021-09-15T09:14:13Z
dc.date.available2021-09-15T09:14:13Z
dc.date.issued2020en_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractObjective: In this study, we aimed to investigate the changes in the levels of oxidative stress and antioxidant enzymes on the mandibular bone caused by the expression of aquaporin-1 and aquaporin-3 proteins. Material and method: 14 Balb/C white mice were divided into two groups of seven, based on whether they are young or old. Mandibular tissue samples were taken for biochemical and histological analysis. Results: Findings of our study has shown that, AQP-1 and AQP-3 immunoreactivity significantly decreased in mandibular bone tissues of aged mice in comparison to younger mice (p < 0.05). MDA and AOPP levels, which are the indicators of oxidative stress, increased in elderly mice and antioxidant defense system SOD enzyme activity was decreased (p < 0.05). The TNF-α cytokine level, which is the indicator for inflammations, was found to be higher in older mice than in young mice (p < 0.05). Conclusion: As a result, it was observed that cellular damage, disruption in water – electrolyte balance and increased inflammation that occur during the natural process of aging had caused serious and irreversible disturbances.en_US
dc.identifier.endpage629en_US
dc.identifier.issue5en_US
dc.identifier.startpage621en_US
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85096934920&doi=10.1515%2fTJB-2019-0174&origin=inward&txGid=7297459af11250ec00ba94df25da79fd
dc.identifier.urihttps://hdl.handle.net/20.500.12514/2845
dc.identifier.volume45en_US
dc.identifier.wosWOS:000582568000020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Journal of Biochemistryen_US
dc.relation.ispartofTurkish Journal of Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAquaporin-1, Aquaporin-3, Oxidative stress, TNF-alphaen_US
dc.titleInvestigation of the relationship cellular and physiological degeneration in the mandible with AQP1 and AQP3 membrane proteinsen_US
dc.typeArticleen_US

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