Synthesis of Novel Acyclic Nucleoside Analogue Starting From 6-Aminouracil as Potent Antimicrobial Agent

6-Aminouracil and 2-bromoethyl amine were prepared, as starting materials to be introduced as an alkylating reagent with sodium carbonate as a catalyst. Acyclic nucleoside was prepared for the first time, the expected structure of the final new compound 3 was determined based on IR, NMR, and mass spectroscopy, with safe and mild reaction conditions. The synthesized acyclic nucleoside has a potent and efficient antimicrobial activity compared to reference drugs particularly as an antibacterial agent, and can be used as an alternative to the commonly used antibiotics after performing the necessary biological research for its validation.

Anahtar Kelimeler

6-aminouracil; acyclic nucleoside analogues; antimicrobial; bromoethylamine; Synthesis

Kaynak

Polycyclic Aromatic Compounds

WoS Q Değeri

Q3

Scopus Q Değeri

N/A

Künye

Alhilal, M., Sulaiman, Y. A. M., Alhilal, S., Gomha, S. M., & Ouf, S. A. (2021). Synthesis of Novel Acyclic Nucleoside Analogue Starting From 6-Aminouracil as Potent Antimicrobial Agent. In Polycyclic Aromatic Compounds (pp. 1–12). Informa UK Limited. https://doi.org/10.1080/10406638.2021.1984260

Bağlantı

https://doi.org/10.1080/10406638.2021.1984260
https://www.scopus.com/record/display.uri?eid=2-s2.0-85116394471&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=b2460a60497608b13f2fead421e7c9b5
https://hdl.handle.net/20.500.12514/2892
https://www.webofscience.com/wos/woscc/full-record/WOS:000702196400001?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=F2yD84a3mpZOfw1zNMF

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Scopus İndeksli Yayınlar Koleksiyonu
Hemşirelik Bölümü Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu

Detaylı Öğe Kaydı

Synthesis of Novel Acyclic Nucleoside Analogue Starting From 6-Aminouracil as Potent Antimicrobial Agent

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