Synthesis of Novel Acyclic Nucleoside Analogue Starting From 6-Aminouracil as Potent Antimicrobial Agent

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dc.authorid0000-0002-2832-8409en_US
dc.contributor.authorAlhilal, Mohammad
dc.contributor.authorSulaiman, Yaser A. M.
dc.contributor.authorAlhilal, Suzan
dc.contributor.authorGomha, Sobhi M.
dc.contributor.authorOuf, Salama A.
dc.date.accessioned2021-10-20T12:13:36Z
dc.date.available2021-10-20T12:13:36Z
dc.date.issued2021en_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümüen_US
dc.description.abstract6-Aminouracil and 2-bromoethyl amine were prepared, as starting materials to be introduced as an alkylating reagent with sodium carbonate as a catalyst. Acyclic nucleoside was prepared for the first time, the expected structure of the final new compound 3 was determined based on IR, NMR, and mass spectroscopy, with safe and mild reaction conditions. The synthesized acyclic nucleoside has a potent and efficient antimicrobial activity compared to reference drugs particularly as an antibacterial agent, and can be used as an alternative to the commonly used antibiotics after performing the necessary biological research for its validation.en_US
dc.identifier.citationAlhilal, M., Sulaiman, Y. A. M., Alhilal, S., Gomha, S. M., & Ouf, S. A. (2021). Synthesis of Novel Acyclic Nucleoside Analogue Starting From 6-Aminouracil as Potent Antimicrobial Agent. In Polycyclic Aromatic Compounds (pp. 1–12). Informa UK Limited. https://doi.org/10.1080/10406638.2021.1984260en_US
dc.identifier.doi10.1080/10406638.2021.1984260en_US
dc.identifier.scopus2-s2.0-85116394471en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1080/10406638.2021.1984260
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85116394471&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=b2460a60497608b13f2fead421e7c9b5
dc.identifier.urihttps://hdl.handle.net/20.500.12514/2892
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000702196400001?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=F2yD84a3mpZOfw1zNMF
dc.identifier.wosWOS:000702196400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPolycyclic Aromatic Compoundsen_US
dc.relation.ispartofPolycyclic Aromatic Compoundsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject6-aminouracil; acyclic nucleoside analogues; antimicrobial; bromoethylamine; Synthesisen_US
dc.titleSynthesis of Novel Acyclic Nucleoside Analogue Starting From 6-Aminouracil as Potent Antimicrobial Agenten_US
dc.typeArticleen_US

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